Acceleration of the world’s first autotaxin inhibitor for the treatment of pancreatic cancer (PDAC)

Project Information

CURE-PDAC

Grant agreement ID: 190159801

DOI

10.3030/190159801

Project closed

EC signature date 6 April 2023

Start date 1 October 2022

End date 31 March 2025

Funded under

• The European Innovation Council (EIC)

Total cost

€ 5 906 503,00

EU contribution

€ 2 500 000,00

Coordinated by

IONCTURA BV
Netherlands

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Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (5)

Pancreatic CAF-Derived Autotaxin Drives Autocrine CTGF Expression to Modulate Protumorigenic Signaling

Author(s): Fanny Volat, Ragini Medhi, Lauren Z. Maggs, Marcel A. Deken, Alice Price, Lauren Andrews, Jonathan Clark, Diane Taylor, Alan Carruthers, Ewan Taylor-Smith, Natalia Pacheco, Simon A. Rudge, Amy Fraser, Andrea F. Lopez-Clavijo, Bebiana C. Sousa, Zoë Johnson, Giusy Di Conza, Lars van der Veen, Pritom Shah, Hilary Sandig, Hayley J. Sharpe, Stuart Farrow
Published in: Molecular Cancer Therapeutics, Issue 24, 2025, ISSN 1535-7163
Publisher: American Association for Cancer Research (AACR)
DOI: 10.1158/1535-7163.MCT-23-0522

Cancer Research

Author(s): Silvia Pietrobono; Fabio Sabbadini; Monica Bertolini; Domenico Mangiameli; Veronica De Vita; Federica Fazzini; Giulia Lunardi; Simona Casalino;
Published in: Cancer Research, 2024, ISSN 0008-5472
Publisher: American Association for Cancer Research
DOI: 10.1158/0008-5472.CAN-23-0104

Autotaxin inhibitor IOA-289 reduces gastrointestinal cancer progression in preclinical models

Author(s): Matteo Centonze, Giusy Di Conza, Michael Lahn, Isabel Fabregat, Francesco Dituri, Isabella Gigante, Grazia Serino, Rosanna Scialpi, Livianna Carrieri, Roberto Negro, Elena Pizzuto & Gianluigi Giannelli
Published in: Journal of Experimental & Clinical Cancer Research, 2023, ISSN 1756-9966
Publisher: BMC
DOI: 10.1186/s13046-023-02780-4

Characterization and translational development of IOA-289, a novel autotaxin inhibitor for the treatment of solid tumors

Author(s): M.A. Deken K. Niewola-Staszkowska O. Peyruchaud N. Mikulčić M. Antolić P. Shah A. Cheasty A. Tagliavini A. Nizzardo M. Pergher L. Ziviani S. Milleri C. Pickering M. Lahn L. van der Veen G. Di Conza Z. Johnson
Published in: IOTECH immuno-oncology and technology, 2023, ISSN 2590-0188
Publisher: ESMO
DOI: 10.1016/j.iotech.2023.100384

High levels of autotaxin and lysophosphatidic acid predict poor outcome in treatment of resectable gastric carcinoma

Author(s): Annalisa Schirizzi, Rossella Donghia, Valentina De Nunzio, Natasha Renna, Matteo Centonze, Giampiero De Leonardis, Vincenza Lorusso, Alessia Fantasia, Sergio Coletta, Dolores Stabile, Annalisa Ferro, Maria Notarnicola, Angela D. Ricci, Claudio Lotesoriere, Michael Lahn, Rosalba D’Alessandro, Gianluigi Giannelli
Published in: European Journal of Cancer, Issue 213, 2024, ISSN 0959-8049
Publisher: Elsevier BV
DOI: 10.1016/J.EJCA.2024.115066

Conference proceedings (1)

Cancers

Author(s): Xiaoyun Tang, Andrew J. Morris, Marcel A. Deken and David N. Brindley
Published in: Cancers, 2023, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers15112937

Intellectual Property Rights

Patent (2)

AUTOTAXIN (ATX) INHIBITOR FOR THE TREATMENT OF PANCREATIC CANCER

Application/Publication number: 20 22065562
Date: 2022-06-08
Applicant(s): IONCTURA BV

METHODS OF TREATMENT OF NON-PANCREATIC GASTROINTESTINAL CANCERS

Application/Publication number: 20 24064995
Date: 2024-05-31
Applicant(s): IONCTURA BV