Objective The TNF Receptor Associated Syndrome (TRAPS) is a rare disease of innate immunity, caused by mutations in TNFR1. It is characterised by recurrent bouts of fever and pain and mainly affects patients of European ancestry. The development of renal amyloidosis in up to 20% of cases makes it a potentially fatal disease. Corticosteroids and anti-TNF therapeutics have not been consistently effective in controlling attacks and preventing amyloidosis. EUROTRAPS is a multidisciplinary consortium, which by combining ideas, resources, and data from 7 academic participants and 2 SMEs from 6 countries, aims to gain insights into the natural course and pathophysiology of TRAPS, particularly in children. The creation of a European registry for TRAPS patients will facilitate the delineation of scores and outcome measures for diagnosis and treatment. We will examine additional pathways and genes involved in the phenotype. Kit assays will be developed to facilitate identification of disease mutations and susceptibility factors for amyloidosis and resistance to treatment. TNFR1 signalling, apoptosis and IL1 secretion abnormalities associated with TRAPS will be studied. We will also develop in vitro and humanised animal models to investigate innovative therapies. We expect that future developments in TRAPS will impact on all aspects of hereditary paediatric fevers, and thereby improve the wellbeing of patients and their families. A dedicated bipartite committee will undertake the complex task of managing this ambitious project, create a secure intranet, organise regular meetings, issue progress reports, oversee ethical, legal, financial, and gender issues (over 50% of the participants are female), adjust the workplan at each milestone, and guarantee dissemination, exploitation and protection of scientific information. The requested funding will cover salaries (over 200 person/months newly generated employments), equipment acquisition, consumables, and dissemination of knowledge. Fields of science medical and health sciencesbasic medicinephysiologypathophysiologynatural sciencesbiological sciencesgeneticsmutationsocial scienceseconomics and businessbusiness and managementemployment Keywords Auto-inflammatory Hereditary recurrent fevers Immunity Innate Natural course Pathophysiology TRAPS Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Topic(s) HEALTH-2007-2.4.4-1 - Natural course and pathophysiology of rare diseases Call for proposal FP7-HEALTH-2007-A See other projects for this call Funding Scheme CP-FP - Small or medium-scale focused research project Coordinator CENTRE HOSPITALIER UNIVERSITAIRE MONTPELLIER EU contribution € 556 071,00 Address AVENUE DU DOYEN GASTON GIRAUD 191 34000 Montpellier France See on map Region Occitanie Languedoc-Roussillon Hérault Activity type Research Organisations Administrative Contact Valérie Thorin (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Participants (8) Sort alphabetically Sort by EU Contribution Expand all Collapse all INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE France EU contribution € 328 904,00 Address RUE DE TOLBIAC 101 75654 Paris See on map Region Ile-de-France Ile-de-France Paris Activity type Research Organisations Administrative Contact William Lepetit (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITY OF LEEDS United Kingdom EU contribution € 340 575,00 Address WOODHOUSE LANE LS2 9JT Leeds See on map Region Yorkshire and the Humber West Yorkshire Leeds Activity type Higher or Secondary Education Establishments Administrative Contact Kathy Brownridge (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITY COLLEGE LONDON EU contribution € 329 307,00 Address GOWER STREET WC1E 6BT LONDON See on map Activity type Higher or Secondary Education Establishments Administrative Contact Kent Lee (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data ISTITUTO GIANNINA GASLINI Italy EU contribution € 334 162,00 Address VIA GEROLAMO GASLINI 5 16147 Genova See on map Region Nord-Ovest Liguria Genova Activity type Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) Administrative Contact Patrizia Fabrizi (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data FONDAZIONE IRCCS POLICLINICO SAN MATTEO Italy EU contribution € 319 600,00 Address VIALE GOLGI 19 27100 Pavia See on map Region Nord-Ovest Lombardia Pavia Activity type Research Organisations Administrative Contact Stefania Zavattoni (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data CHARITE - UNIVERSITAETSMEDIZIN BERLIN Germany EU contribution € 106 440,00 Address Chariteplatz 1 10117 Berlin See on map Region Berlin Berlin Berlin Activity type Higher or Secondary Education Establishments Administrative Contact Eveline Fräßdorf (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data PRONTO DIAGNOSTICS LTD Israel EU contribution € 322 150,00 Address KIRYAT ATIDIM BUILDING 3 2ND ENTRANCE 6158002 Tel Aviv See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Gill Sher (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data VIENNALAB DIAGNOSTICS GMBH Austria EU contribution € 326 016,00 Address Gaudenzdorfer Guertel 43-45 1120 VIENNA See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Andreas Kofler (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data
