Objective
The overall objective of UNICELLSYS is a quantitative understanding of fundamental characteristics of eukaryotic unicellular organism biology: how cell growth and proliferation are controlled and coordinated by extracellular and intrinsic stimuli. Achieving an understanding of the principles with which bio-molecular systems function requires integrating quantitative experimentation with simulations of dynamic mathematical models. UNICELLSYS bring together a consortium of leading European experimental and computational systems biologists that will study cell growth and proliferation at the levels of cell population, single cell, cellular network, large-scale dynamic systems and functional module. Building computational reconstructions and dynamic models will involve different precise quantitative measurements as well as complementary approaches of mathematical modelling. A major challenge will be the generation of comprehensive dynamic models of the entire control system of cell growth and proliferation, which will require integration of smaller sub-models and reduction of complexity. Implementation of the models will allow observing responses to altered growth conditions zooming in seamlessly from populations consisting of cells of different replicative age and cell cycle stage via genome-wide molecular networks, large dynamic systems to detailed functional modules. Employing computational simulations combined with experimentation will allow discovering new and emerging principles of bio-molecular organisation and analysing the control mechanisms of cell growth and proliferation. The project will deliver new knowledge on fundamental eukaryotic biology as well as tools for quantitative experimentation and modelling. Detailed plans for dissemination and exploitation will ensure that UNICELLSYS will have major impact on the development of Systems Biology in Europe ensuring a competitive advantage of Europe in dynamic quantitative modelling of bio-molecular processes.
Field of science
- /natural sciences/mathematics/applied mathematics/mathematical model
- /engineering and technology/electrical engineering, electronic engineering, information engineering/electronic engineering/automation and control systems
Call for proposal
FP7-HEALTH-2007-A
See other projects for this call
Funding Scheme
CP-IP - Large-scale integrating project
Coordinator
405 30 Goeteborg
Sweden
Participants (17)
41288 Goeteborg
2800 Kgs Lyngby
8092 Zuerich
08002 Barcelona
08003 Barcelona
M13 9PL Manchester
SY23 3BF Aberystwyth
20126 Milano
80539 Muenchen
OX1 2JD Oxford
1090 Wien
EH8 9YL Edinburgh
41296 Goeteborg
CB2 1TN Cambridge
10117 Berlin
1081 HV Amsterdam
1081 HV Amsterdam
