Obiettivo
The overall objective of UNICELLSYS is a quantitative understanding of fundamental characteristics of eukaryotic unicellular organism biology: how cell growth and proliferation are controlled and coordinated by extracellular and intrinsic stimuli. Achieving an understanding of the principles with which bio-molecular systems function requires integrating quantitative experimentation with simulations of dynamic mathematical models. UNICELLSYS bring together a consortium of leading European experimental and computational systems biologists that will study cell growth and proliferation at the levels of cell population, single cell, cellular network, large-scale dynamic systems and functional module. Building computational reconstructions and dynamic models will involve different precise quantitative measurements as well as complementary approaches of mathematical modelling. A major challenge will be the generation of comprehensive dynamic models of the entire control system of cell growth and proliferation, which will require integration of smaller sub-models and reduction of complexity. Implementation of the models will allow observing responses to altered growth conditions zooming in seamlessly from populations consisting of cells of different replicative age and cell cycle stage via genome-wide molecular networks, large dynamic systems to detailed functional modules. Employing computational simulations combined with experimentation will allow discovering new and emerging principles of bio-molecular organisation and analysing the control mechanisms of cell growth and proliferation. The project will deliver new knowledge on fundamental eukaryotic biology as well as tools for quantitative experimentation and modelling. Detailed plans for dissemination and exploitation will ensure that UNICELLSYS will have major impact on the development of Systems Biology in Europe ensuring a competitive advantage of Europe in dynamic quantitative modelling of bio-molecular processes.
Campo scientifico
- engineering and technologyelectrical engineering, electronic engineering, information engineeringelectronic engineeringcontrol systems
- engineering and technologyelectrical engineering, electronic engineering, information engineeringinformation engineeringtelecommunicationstelecommunications networksmobile network
- natural sciencesmathematicsapplied mathematicsmathematical model
Parole chiave
Invito a presentare proposte
FP7-HEALTH-2007-A
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Meccanismo di finanziamento
CP-IP - Large-scale integrating projectCoordinatore
405 30 Goeteborg
Svezia
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Partecipanti (17)
41288 GOETEBORG
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2800 Kongens Lyngby
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8092 Zuerich
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08002 Barcelona
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08003 Barcelona
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M13 9PL Manchester
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SY23 3BF Aberystwyth
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20126 MILANO
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80539 Munchen
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OX1 2JD Oxford
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1090 Wien
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EH8 9YL Edinburgh
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412 96 GOTEBORG
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CB2 1TN Cambridge
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10117 Berlin
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1081 HV Amsterdam
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1081 HV Amsterdam
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