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REvolutionary Approaches and Devices for Nucleic Acid Analysis

Objective

The REvolutionary Approaches and Devices for Nucleic Acid analysis – READNA – consortium is composed of researchers from 10 academic institutions, 5 SMEs and 3 large companies. The goals of the READNA consortium are to revolutionize nucleic acid analysis methods, by 1) improving elements necessary to use the currently emerging generation of nucleic acid sequencers in a meaningful and accessible way, 2) providing methods that allow in situ nucleic acid analysis and methods capable of selectively characterizing mutant DNA in a high background of wildtype DNA, 3) combining RNA and DNA analysis in a single analytical device, 4) providing technology to efficiently analyze DNA methylation (genome-wide, with high resolution and in its long-range context), 5) implementing novel concepts for high-throughput HLA-screening, 6) developing fully integrated solutions for mutational screening of small target regions (such as for screening newborns for cystic fibrosis mutations), 7) developing a device for screening multiple target regions with high accuracy, and 8) implementing strategies for effective and high-resolution genotyping of copy number variations. An important part of READNA is dedicated to the development of the next generation of nucleic analysis devices on individual DNA molecules by stretching out nucleic acid molecules in nanosystems, using alpha-hemolysing nanopores and carbon nanotubes. These approaches will benefit from improved interrogation and detection strategies which we will develop. Our methods and devices will boost the possibilities of genetic research by closing in on the target of 1000 Euros for the sequence of a complete human genome, while at the same time leading a revolution in cost-effective, non-invasive early screening for diseases such as cancer.

Field of science

  • /natural sciences/biological sciences/biochemistry/biomolecules/nucleic acid
  • /natural sciences/biological sciences/genetics and heredity/mutation
  • /medical and health sciences/clinical medicine/oncology/cancer
  • /natural sciences/biological sciences/genetics and heredity/genome

Call for proposal

FP7-HEALTH-2007-A
See other projects for this call

Funding Scheme

CP-IP - Large-scale integrating project

Coordinator

COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
Address
Rue Leblanc 25
75015 Paris 15
France
Activity type
Research Organisations
EU contribution
€ 2 112 971,17
Administrative Contact
Elizabeth May (Ms.)

Participants (19)

UPPSALA UNIVERSITET
Sweden
EU contribution
€ 764 960
Address
Von Kraemers Alle 4
751 05 Uppsala
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Pirkko Boox (Ms.)
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom
EU contribution
€ 2 094 491,40
Address
Wellington Square University Offices
OX1 2JD Oxford
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Linda Pialek (Ms.)
UNIVERSITY OF LEICESTER
United Kingdom
EU contribution
€ 1 035 000
Address
University Road
LE1 7RH Leicester
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Marie Adams (Ms.)
Klinik Max Planck Institut für Psychiatrie
Germany
EU contribution
€ 1 053 769
Address
Hofgartenstrasse 8
80539 Muenchen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Anke Badrow (Ms.)
TECHNISCHE UNIVERSITEIT DELFT
Netherlands
EU contribution
€ 932 318
Address
Stevinweg 1
2628 CN Delft
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Edward Waaijer (Mr.)
MAX IV Laboratory, Lund University

Participation ended

Sweden
Address
Paradisgatan 5C
22100 Lund
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Lars Montelius (Prof.)
UNIVERSITY OF SOUTHAMPTON
United Kingdom
EU contribution
€ 460 243
Address
Highfield
SO17 1BJ Southampton
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Yan Qiao (Ms.)
CHRISTIAN-ALBRECHTS-UNIVERSITAET ZU KIEL
Germany
EU contribution
€ 401 213
Address
Olshausenstrasse 40
24118 Kiel
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Ingmar Schmidt (Dr.)
DANMARKS TEKNISKE UNIVERSITET
Denmark
EU contribution
€ 353 725
Address
Anker Engelundsvej 1 Bygning 101 A
2800 Kgs Lyngby
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Birgitte Brandrup (Ms.)
NAVINCI DIAGNOSTICS AB
Sweden
EU contribution
€ 599 076
Address
Uppsala University Bmc D11 Plan 1 Husargatan 3
752 37 Uppsala
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Bjorn Ekstrom (Mr.)
OXFORD NANOPORE TECHNOLOGIES LTD
United Kingdom
EU contribution
€ 730 000
Address
Robert Robinson Avenue - Oxford Science Park 4
OX4 4GA Oxford
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Jim Mcdonald (Mr.)
PHOTONIS FRANCE SAS
France
EU contribution
€ 74 700
Address
Avenue Roger Roncier
19109 Brive La Gaillarde
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Emile Schyns (Dr.)
PHILIPS ELECTRONICS NEDERLAND BV
Netherlands
EU contribution
€ 18 250
Address
High Tech Campus 52
5656 AG Eindhoven
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Patrick Keur (Mr.)
HUMMINGBIRD DIAGNOSTICS GMBH
Germany
EU contribution
€ 166 605
Address
Im Neuenheimer Feld 583
69120 Heidelberg
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Jochen Kohlhaas (Mr.)
LIFE TECHNOLOGIES GmbH
Germany
EU contribution
€ 6 037,43
Address
Frankfurter Strasse 129 B
64293 Darmstadt
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Angelika Hausmann (Ms.)
FlexGen B.V.
Netherlands
EU contribution
€ 100 000
Address
Wassenaarseweg 72
2333AL Leiden
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Yvon Van Den Hout (Ms.)
GENEWAVE SAS
France
EU contribution
€ 24 934
Address
Rue Pierre Fontaine 4
91000 Evry
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Philippe Loiseau (Dr.)
GOETEBORGS UNIVERSITET
Sweden
EU contribution
€ 549 986
Address
Vasaparken
405 30 Goeteborg
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Ludde Edgren (Dr.)
FUNDACIO PARC CIENTIFIC DE BARCELONA
Spain
EU contribution
€ 514 040
Address
Baldiri I Reixac 4
08028 Barcelona
Activity type
Research Organisations
Administrative Contact
Moises Tarté (Mr.)