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REvolutionary Approaches and Devices for Nucleic Acid Analysis

Obiettivo

The REvolutionary Approaches and Devices for Nucleic Acid analysis – READNA – consortium is composed of researchers from 10 academic institutions, 5 SMEs and 3 large companies. The goals of the READNA consortium are to revolutionize nucleic acid analysis methods, by 1) improving elements necessary to use the currently emerging generation of nucleic acid sequencers in a meaningful and accessible way, 2) providing methods that allow in situ nucleic acid analysis and methods capable of selectively characterizing mutant DNA in a high background of wildtype DNA, 3) combining RNA and DNA analysis in a single analytical device, 4) providing technology to efficiently analyze DNA methylation (genome-wide, with high resolution and in its long-range context), 5) implementing novel concepts for high-throughput HLA-screening, 6) developing fully integrated solutions for mutational screening of small target regions (such as for screening newborns for cystic fibrosis mutations), 7) developing a device for screening multiple target regions with high accuracy, and 8) implementing strategies for effective and high-resolution genotyping of copy number variations. An important part of READNA is dedicated to the development of the next generation of nucleic analysis devices on individual DNA molecules by stretching out nucleic acid molecules in nanosystems, using alpha-hemolysing nanopores and carbon nanotubes. These approaches will benefit from improved interrogation and detection strategies which we will develop. Our methods and devices will boost the possibilities of genetic research by closing in on the target of 1000 Euros for the sequence of a complete human genome, while at the same time leading a revolution in cost-effective, non-invasive early screening for diseases such as cancer.

Campo scientifico

Parole chiave

Programma(i)

Argomento(i)

Invito a presentare proposte

FP7-HEALTH-2007-A
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Meccanismo di finanziamento

CP-IP - Large-scale integrating project

Coordinatore

COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
Contributo UE
€ 2 112 971,17
Indirizzo
RUE LEBLANC 25
75015 PARIS 15
Francia

Mostra sulla mappa
Regione
Ile-de-France Ile-de-France Paris
Tipo di attività
Research Organisations
Contatto amministrativo
Elizabeth May (Ms.)
Collegamenti
Costo totale
Nessun dato

Partecipanti (19)

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Ultimo aggiornamento: 16 Luglio 2019

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Permalink: https://cordis.europa.eu/project/id/201418/it

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