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An integrated concept of tumor metastasis: implications for therapy

Objective

From many perspectives our concept of the process of metastasis is inadequate and needs to be revised. In particular, the potential impact of recent ideas about the cellular basis of tumor growth (cancer stem cells) and the establishment by remote tumors of special permissive microenvironments in target organs prior to metastasis (metastatic niches) remains to be explored. In the TuMIC project we will use novel experimental approaches to integrate these newly emerging principles and ideas with the different hypotheses that have until now tried to explain the process of metastasis. Specifically we aim to understand how cancer stem cells behave in and contribute to metastasis, and how networks and pathways that are known to regulate metastasis affect their properties. Further objects are to determine how a permissive microenvironment for metastasis formation is established in given organs, how this contributes to determining patterns of metatasis, and how these microenvironments interact with cancer stem cells. These studies will facilitate the development of an improved and more accurate concept about the process of metastasis. In turn, this will have fundamental ramifications for the way in which novel anti-cancer therapies are designed, and most importantly should provide important new insights into how cancer and in particular metastatic disease can be successfully treated. With this in mind we will also perform preclinical studies that build on TuMIC findings with the aim of developing novel anti-cancer therapies.

Field of science

  • /medical and health sciences/medical biotechnology/cells technologies/stem cells
  • /medical and health sciences/clinical medicine/cancer

Call for proposal

FP7-HEALTH-2007-A
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG
Address
Seminarstrasse 2
69117 Heidelberg
Germany
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 501 388,88
Administrative Contact
Norbert Huber (Dr.)

Participants (13)

UNIVERSITAT BASEL
Switzerland
EU contribution
€ 258 000
Address
Petersplatz 1
4051 Basel
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Gerhard Christofori (Prof.)
ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
Netherlands
EU contribution
€ 258 000
Address
Dr Molewaterplein 40
3015 GD Rotterdam
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Marieke Bootsma (Ms.)
CANCER RESEARCH UK LBG

Participation ended

United Kingdom
EU contribution
€ 170,44
Address
St John Street 407 Angel Building
EC1V 4AD London
Activity type
Research Organisations
Administrative Contact
Kate Malfroy (Ms.)
FONDATION DU CENTRE PLURIDISCIPLINAIRE D'ONCOLOGIE

Participation ended

Switzerland
EU contribution
€ 159 176,64
Address
Rue Du Bugnon 46
1011 Lausanne
Activity type
Research Organisations
Administrative Contact
Chantal Vonlanthen-Clerc (Ms.)
STICHTING HET NEDERLANDS KANKER INSTITUUT-ANTONI VAN LEEUWENHOEK ZIEKENHUIS
Netherlands
EU contribution
€ 253 200
Address
Plesmanlaan 121
1066 CX Amsterdam
Activity type
Research Organisations
Administrative Contact
Jantien Mandres (Ms.)
UNIVERSITA DEGLI STUDI DI NAPOLI FEDERICO II
Italy
EU contribution
€ 241 200
Address
Corso Umberto I, 40
80138 Napoli
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Massimo Zollo (Prof.)
KRAEFTENS BEKAEMPELSE
Denmark
EU contribution
€ 258 000
Address
Strandboulevarden 49
2100 Koebenhavn
Activity type
Research Organisations
Administrative Contact
David Mollerup (Mr.)
VIB VZW
Belgium
EU contribution
€ 258 000
Address
Rijvisschestraat 120
9052 Zwijnaarde - Gent
Activity type
Research Organisations
Administrative Contact
Wim Goemaere (Mr.)
ACTELION PHARMACEUTICALS LTD
Switzerland
EU contribution
€ 248 150
Address
Gewerbestrasse 16
4123 Allschwil
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Urs Regenass (Dr.)
INSTITUT CURIE
France
EU contribution
€ 219 600
Address
Rue D'ulm 26
75231 Paris
Activity type
Research Organisations
Administrative Contact
Corinne Cumin (Ms.)
FORSCHUNGSZENTRUM KARLSRUHE GMBH

Participation ended

Germany
EU contribution
€ 583,12
Address
Weberstrasse 5
76133 Karlsruhe
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Anke Schmidt (Ms.)
THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE
United Kingdom
EU contribution
€ 257 829,56
Address
Trinity Lane The Old Schools
CB2 1TN Cambridge
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Edna Murphy (Ms.)
UNIVERSITE DE FRIBOURG
Switzerland
EU contribution
€ 85 886,36
Address
Avenue De L Europe 20
1700 Fribourg
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Monique Bersier (Ms.)