Objectif Tuberculosis (TB) continues being a leading cause of death due to a single infectious disease agent. The HIV/AIDS pandemic and the emergence of drug resistance are compounding factors that hinder the control of the disease. Associated with this problem is the emergence of multidrug-resistant (MDR) strains of Mycobacterium tuberculosis, defined as strains resistant to at least isoniazid and rifampicin, the most valuable drugs in the treatment of the disease. More recently, the appearance of extensively drug resistant (XDR) strains has been reported. These strains, in addition to being MDR, are also resistant to key second-line drugs. Patients, especially HIV patients, harbouring XDR strains have virtually no treatment options. New and improved methods for fast detection of drug resistance are urgently needed. This project will develop a twofold-approach system for the fast and simultaneous detection of MDR and XDR strains based on a rapid phenotypic assay and a genotypic test. Colorimetric methods, which have been previously validated by our group for first-line drug susceptibility testing, will be developed for key second-line drugs involved in XDRTB. Once set up, these methods will be further elaborated for direct application to sputum specimens. The molecular tool will be based on a modification of the novel technology named detection of immobilized amplified product in one phase system. This single step amplification method will be developed in a versatile microtitre well strip format for detection first of MDR and then of XDR strains. The tools will be then validated in different settings and prospectively evaluated in target populations. The project will contribute to the currently available armamentarium for rapid detection of drug resistant TB and will introduce new tools for the detection of the recently-described and highly-lethal XDRTB. It will also contribute to our knowledge on the mechanisms of M. tuberculosis resistance to second-line drugs. Champ scientifique medical and health scienceshealth sciencesinfectious diseasesRNA virusesHIVmedical and health sciencesclinical medicinepneumologytuberculosismedical and health sciencesbasic medicinepharmacology and pharmacydrug resistancemultidrug resistance Mots‑clés MDR XDR drug resistance fast detection new tests tuberculosis Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Thème(s) HEALTH-2007-2.3.2-3 - Development of fast tests for the diagnosis of Multi-Drug-Resistant strains of HIV, malaria and tuberculosis and of latent tuberculosis infection (LTBI) Appel à propositions FP7-HEALTH-2007-A Voir d’autres projets de cet appel Régime de financement CP-FP - Small or medium-scale focused research project Coordinateur INSTITUUT VOOR TROPISCHE GENEESKUNDE Contribution de l’UE € 868 985,00 Adresse NATIONALESTRAAT 155 2000 ANTWERPEN Belgique Voir sur la carte Région Vlaams Gewest Prov. Antwerpen Arr. Antwerpen Type d’activité Higher or Secondary Education Establishments Contact administratif Jef Van Lint (Mr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée Participants (7) Trier par ordre alphabétique Trier par contribution de l’UE Tout développer Tout réduire HELMHOLTZ-ZENTRUM FUR INFEKTIONSFORSCHUNG GMBH Allemagne Contribution de l’UE € 336 000,00 Adresse INHOFFENSTRASSE 7 38124 Braunschweig Voir sur la carte Région Niedersachsen Braunschweig Braunschweig, Kreisfreie Stadt Type d’activité Research Organisations Contact administratif Michael Strätz (Dr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée SMITTSKYDDSINSTITUTET Suède Contribution de l’UE € 420 000,00 Adresse Nobels vaeg 18 17182 SOLNA Voir sur la carte Type d’activité Research Organisations Contact administratif Bengt-åke Andersson (Mr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée LIONEX GMBH Allemagne Contribution de l’UE € 330 300,00 Adresse Salzdahlumer Strasse 196 38126 Braunschweig Voir sur la carte Région Niedersachsen Braunschweig Braunschweig, Kreisfreie Stadt Type d’activité Private for-profit entities (excluding Higher or Secondary Education Establishments) Contact administratif Mahavir Singh (Prof.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée LATVIJAS INFEKTOLOGIJAS CENTRS (INFECTOLOGY CENTER OF LATVIA) Lettonie Contribution de l’UE € 125 200,00 Adresse LINEZERA IELA 3 1006 RIGA Voir sur la carte Type d’activité Research Organisations Contact administratif Girts Skenders (Dr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée CORPORACION CORPOGEN Colombie Contribution de l’UE € 352 200,00 Adresse Carrera 5 N° 66A-34 N/A BOGOTA Voir sur la carte Type d’activité Research Organisations Contact administratif Patricia Del Portillo (Ms.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée ADMINISTRACION NACIONAL DE LABORATORIOS E INSTITUTOS DE SALUD DR. CARLOS G. MALBRAN Argentine Contribution de l’UE € 131 200,00 Adresse Avenida Velez Sarsfield 563 1281 BUENOS AIRES Voir sur la carte Type d’activité Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) Contact administratif Laura Boveri (Ms.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée HOSPITAL ZONAL ESPECIALIZADO DE AGUDOS Y CRONICOS DR. CETRANGOLO Argentine Contribution de l’UE € 131 680,00 Adresse Italia 1750 1602 VICENTE LOPEZ Voir sur la carte Type d’activité Research Organisations Contact administratif Laura Boveris (Ms.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée
