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Ultra-high resolution and ultra-sensitive fluorescence methods for objective sub-cellular diagnosis of early disease and disease progression in breast and prostate cancer

Objectif

The overall objective of this proposal is to develop and validate a quantitative, minimally invasive diagnostic tool for early and conclusive detection, diagnosis and monitoring of disease and disease progression of breast and prostate cancer. A methodology will be developed making use of a combination of the probably most exciting recent advances in the field of light microscopy, for fluorescence-based optical imaging of individual sample cells. It includes advances which will take the spatial resolution far beyond the fundamental limits of optical resolution, the sensitivity down to an ultimate single-molecule level, and multi-parameter detection schemes significantly increasing the fluorescence information by which these cellular images can be analysed. Apart from detecting and identifying tumour markers in the samples, tumour-specific spatio-temporal molecular distributions within the intact sample cells will be exploited. This is to date an almost unexploited dimension of diagnostic information. By combining and supporting these novel optical methods with state-of-the-art affinity molecule biotechnology, , tumor biomarkers, fluorophore chemistry, and bioinformatic validation tools, all possible means will be exploited to extract a maximum amount of information out of very small amounts of sample material. We thereby expect that an improved, early and reliable diagnosis of breast and prostate cancer will be possible, from amounts of sample material small enough that a minimally invasive procedure such as Fine-needle aspiration (FNA) can be used. In addition, by the minimally invasive FNA-based sampling, serious sampling-related side-effects, such as seeding and spread of cancer cells can be completely avoided. Given the high incidence of breast and prostate cancer, and the utmost importance of an early and conclusive diagnosis for the prognosis of these diseases, the relevance of this project can not be overestimated.

Appel à propositions

FP7-HEALTH-2007-A
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Régime de financement

CP-FP - Small or medium-scale focused research project

Coordinateur

KUNGLIGA TEKNISKA HOEGSKOLAN
Adresse
Brinellvagen 8
100 44 Stockholm
Suède
Type d’activité
Higher or Secondary Education Establishments
Contribution de l’UE
€ 1 101 193
Contact administratif
Monica Thorén (Ms.)

Participants (11)

NEODYNAMICS AB
Suède
Contribution de l’UE
€ 265 430
Adresse
Ulvsundavagen 181
16867 Bromma
Type d’activité
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contact administratif
Peter Sellei (Mr.)
KAROLINSKA INSTITUTET
Suède
Contribution de l’UE
€ 333 963
Adresse
Nobels Vag 5
17177 Stockholm
Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Riitta Perttunen-Elo (Ms.)
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
Allemagne
Contribution de l’UE
€ 351 116
Adresse
Hofgartenstrasse 8
80539 Muenchen
Type d’activité
Research Organisations
Contact administratif
Manfred Messerschmidt (Mr.)
HEINRICH-HEINE-UNIVERSITAET DUESSELDORF
Allemagne
Contribution de l’UE
€ 451 958
Adresse
Universitaetsstrasse 1
40225 Dusseldorf
Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Uwe Droste (Mr.)
SENSL TECHNOLOGIES LIMITED
Irlande
Contribution de l’UE
€ 361 557
Adresse
Building 6800 Avenue 6000 Cork Airport Business Park
- Cork
Type d’activité
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contact administratif
John Murphy (Dr.)
BECKER & HICKL GMBH
Allemagne
Contribution de l’UE
€ 285 314
Adresse
Nahmitzer Damm 30
12277 Berlin
Type d’activité
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contact administratif
Wolfgang Becker (Dr.)
UNIVERSITAET zu LUEBECK
Allemagne
Contribution de l’UE
€ 270 192
Adresse
Ratzeburger Allee 160
23562 Lubeck
Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Gabriele Huhn (Ms.)
UNIVERSITAET SIEGEN
Allemagne
Contribution de l’UE
€ 177 112
Adresse
Adolf Reichwein Strasse 2A
57076 Siegen
Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Karl Heinz Drexhage (Prof.)
TURUN YLIOPISTO
Finlande
Contribution de l’UE
€ 210 326
Adresse
Yliopistonmaki
20014 Turku
Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Eliisa Särkilahti (Dr.)
HELSINGIN YLIOPISTO
Finlande
Contribution de l’UE
€ 128 604
Adresse
Yliopistonkatu 3
00014 Helsingin Yliopisto
Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Katariina Vainio-Mattila (Ms.)
ACADEMISCH ZIEKENHUIS LEIDEN
Pays-Bas
Contribution de l’UE
€ 261 009
Adresse
Albinusdreef 2
2333 ZA Leiden
Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Linda Ouwerkerk