Objective
Osteoporosis is a common, age-related disease with a strong genetic component. With increasing age of the population, Europe and industrialised countries across the globe are facing a substantial increase in osteoporotic fractures, which account for considerable disease-burden and costs. Early identification and treatment of subjects at risk can help preventing this, and genetic susceptibility alleles are the most promising risk factors in this respect. Large-scale prospective meta-analysis of individual gene polymorphisms in the EU-funded GENOMOS consortium was shown successful in identifying the expected subtle effects of gene polymorphisms which predispose to osteoporosis. The recent development of powerful genome-wide genotyping technology now allows to identify -hypothesis free- strong and common genetic risk factors for complex diseases by Genome Wide Association (GWA) analysis. The AIM of the proposal is to identify osteoporosis susceptibility alleles by meta-analysis of GWA data obtained from a large collection of osteoporosis genetics cohorts in Europe and outside (n=46.000). Prospective meta-analysis of GENOMOS, a large consortium of genetic studies on osteoporosis (n=80.000) is used to assess generalizability of genetic effects and develop sufficient power to quantify even small, but clinically important risks. The improvement in clinical risk-assessment for osteoporosis by adding the diagnostic panel of osteoporosis risk-alleles identified in this project, will be quantified in prospective studies including genetic and classical risk factors.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-HEALTH-2007-A
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
3015 GD Rotterdam
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.