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GENETIC FACTORS FOR OSTEOPOROSIS

Objective

Osteoporosis is a common, age-related disease with a strong genetic component. With increasing age of the population, Europe and industrialised countries across the globe are facing a substantial increase in osteoporotic fractures, which account for considerable disease-burden and costs. Early identification and treatment of subjects at risk can help preventing this, and genetic susceptibility alleles are the most promising risk factors in this respect. Large-scale prospective meta-analysis of individual gene polymorphisms in the EU-funded GENOMOS consortium was shown successful in identifying the expected subtle effects of gene polymorphisms which predispose to osteoporosis. The recent development of powerful genome-wide genotyping technology now allows to identify -hypothesis free- strong and common genetic risk factors for complex diseases by Genome Wide Association (GWA) analysis. The AIM of the proposal is to identify osteoporosis susceptibility alleles by meta-analysis of GWA data obtained from a large collection of osteoporosis genetics cohorts in Europe and outside (n=46.000). Prospective meta-analysis of GENOMOS, a large consortium of genetic studies on osteoporosis (n=80.000) is used to assess generalizability of genetic effects and develop sufficient power to quantify even small, but clinically important risks. The improvement in clinical risk-assessment for osteoporosis by adding the diagnostic panel of osteoporosis risk-alleles identified in this project, will be quantified in prospective studies including genetic and classical risk factors.

Call for proposal

FP7-HEALTH-2007-A
See other projects for this call

Coordinator

ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
Address
Dr Molewaterplein 40
3015 GD Rotterdam
Netherlands
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 197 272
Administrative Contact
Jan Willem Te Ronde (Mr.)

Participants (10)

PANEPISTIMIO IOANNINON
Greece
EU contribution
€ 475 000
Address
Panepistemioypole Panepistemio Ioanninon
45110 Ioannina
Activity type
Higher or Secondary Education Establishments
Administrative Contact
John Ioannidis (Prof.)
THE UNIVERSITY OF EDINBURGH
United Kingdom
EU contribution
€ 245 928
Address
Old College, South Bridge
EH8 9YL Edinburgh
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Angela Noble (Ms.)
ISLENSK ERFDAGREINING EHF
Iceland
EU contribution
€ 250 050
Address
Sturlugotu 8
101 Reykjavik
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Gudmundur Einarsson (Mr.)
KING'S COLLEGE LONDON
United Kingdom
EU contribution
€ 202 200
Address
Strand
WC2R 2LS London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Paul Labbett (Mr.)
THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom
EU contribution
€ 195 600
Address
Trinity Lane The Old Schools
CB2 1TN Cambridge
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Dawn Barker (Ms.)
GOETEBORGS UNIVERSITET
Sweden
EU contribution
€ 223 800
Address
Vasaparken
405 30 Goeteborg
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Margareta Ahlqwist (Dr.)
THE UNIVERSITY OF SHEFFIELD
United Kingdom
EU contribution
€ 208 800
Address
Firth Court Western Bank
S10 2TN Sheffield
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Gill Wells (Ms.)
THE UNIVERSITY OF QUEENSLAND
Australia
Address
St Lucia
4072 Brisbane
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Ian Harris (Mr.)
HEBREW REHABILITATION CENTER
United States
Address
Centre Street 1200
02131 Boston
Activity type
Research Organisations
Administrative Contact
Ted Gruen (Mr.)
CALIFORNIA PACIFIC MEDICAL CENTER RESEACH INSTITUTE
United States
Address
California Street
CA94118 San Fransisco
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
Sarah Love (Ms.)