Objective When restoration of the immune response in older age is the target of basic and clinical research, boosting innate and adaptive immunity, e.g. by more efficient vaccination strategies, is the general approach. However, TOLERAGE has a fundamentally different focus, i.e. restoring the age-dependent decline of auto-tolerance that underlies the development of the paradigmatic age-associated diseases atherosclerosis (AS) and rheumatoid arthritis (RA). These diseases represent the major medical and socioeconomic burden in aging societies. They start earlier in life but become clinically manifest with increasing age. To reach this aim a consortium of ten partner groups was formed that have an outstanding track record in areas of immunology pertinent for this task. The work of TOLERAGE will focus on three major issues, viz. 1. Investigating basic principles of the induction of central and peripheral tolerance in mice against autoantigens, including heat shock protein 60 (HSP60) that has been shown to play a major role in the development of AS and RA. 2. Determination of the mediators of central and peripheral tolerance that are responsible for the T effector/T regulatory cell dysbalance in older age in general and in AS and RA in particular. 3. Translation of the results obtained in (a) and (b) into practical application for the prevention and treatment of AS and RA by appropriate vaccines. For all partners, important technical platforms will be available, including unique transgenic and knockout mouse strains, sophisticated models for in vitro and in vivo transfection of dendritic cells (DCs) and a well established Functional Genomics Facility. Fields of science medical and health scienceshealth sciencesinfectious diseasesRNA virusescoronaviruses Keywords aging atherosclerosi immune system tolerisation Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Topic(s) HEALTH-2007-2.2.2-1 - Novel approaches to reconstitute normal immune function at old age Call for proposal FP7-HEALTH-2007-A See other projects for this call Funding Scheme CP-IP - Large-scale integrating project Coordinator MEDIZINISCHE UNIVERSITAT INNSBRUCK EU contribution € 1 224 500,00 Address CHRISTOPH PROBST PLATZ 1 6020 Innsbruck Austria See on map Region Westösterreich Tirol Innsbruck Activity type Higher or Secondary Education Establishments Administrative Contact Georg Wick (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Participants (9) Sort alphabetically Sort by EU Contribution Expand all Collapse all KANTONSSPITAL ST. GALLEN Switzerland EU contribution € 928 000,00 Address Rorschacherstrasse 95 9007 St. Gallen See on map Region Schweiz/Suisse/Svizzera Ostschweiz St. Gallen Activity type Research Organisations Administrative Contact Burkhard Ludewig (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data KAROLINSKA INSTITUTET Sweden EU contribution € 1 042 000,00 Address Nobels Vag 5 17177 Stockholm See on map Region Östra Sverige Stockholm Stockholms län Activity type Higher or Secondary Education Establishments Administrative Contact Cecilia Tilly (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG Germany EU contribution € 676 240,00 Address IM NEUENHEIMER FELD 280 69120 Heidelberg See on map Region Baden-Württemberg Karlsruhe Heidelberg, Stadtkreis Activity type Research Organisations Administrative Contact Bettina Crispin (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE France EU contribution € 655 600,00 Address RUE DE TOLBIAC 101 75654 Paris See on map Region Ile-de-France Ile-de-France Paris Activity type Research Organisations Administrative Contact Marianne Cottet (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data FONDAZIONE HUMANITAS PER LA RICERCA Italy EU contribution € 786 000,00 Address Via Manzoni 20089 Rozzano See on map Activity type Research Organisations Administrative Contact Danilo Petroni (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITEIT UTRECHT Netherlands EU contribution € 803 591,00 Address HEIDELBERGLAAN 8 3584 CS Utrecht See on map Region West-Nederland Utrecht Utrecht Activity type Higher or Secondary Education Establishments Administrative Contact Alexandra Dijk (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITA' DEGLI STUDI DI MILANO-BICOCCA Italy EU contribution € 565 000,00 Address PIAZZA DELL'ATENEO NUOVO 1 20126 MILANO See on map Region Nord-Ovest Lombardia Milano Activity type Higher or Secondary Education Establishments Administrative Contact Anastasia Sguera (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data FUNCTIONAL GENOMICS CONSORTIUM Italy EU contribution € 806 000,00 Address PIAZZA DELLA SCIENZA 2 UNIVERSITA DEGLI STUDI MILANO 20126 MILAN See on map Activity type Research Organisations Administrative Contact Paola Castagnoli (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data CENTER OF EXCELLENCE IN MEDICINE AND IT GMBH Austria EU contribution € 250 000,00 Address KARL KAPFERER STRASSE 5 6020 INNSBRUCK See on map Region Westösterreich Tirol Innsbruck Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Stefan Masser (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data
