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Normalisation of immune reactivity in old age – from basic mechanisms to clinical application

Ziel

When restoration of the immune response in older age is the target of basic and clinical research, boosting innate and adaptive immunity, e.g. by more efficient vaccination strategies, is the general approach. However, TOLERAGE has a fundamentally different focus, i.e. restoring the age-dependent decline of auto-tolerance that underlies the development of the paradigmatic age-associated diseases atherosclerosis (AS) and rheumatoid arthritis (RA). These diseases represent the major medical and socioeconomic burden in aging societies. They start earlier in life but become clinically manifest with increasing age. To reach this aim a consortium of ten partner groups was formed that have an outstanding track record in areas of immunology pertinent for this task. The work of TOLERAGE will focus on three major issues, viz. 1. Investigating basic principles of the induction of central and peripheral tolerance in mice against autoantigens, including heat shock protein 60 (HSP60) that has been shown to play a major role in the development of AS and RA. 2. Determination of the mediators of central and peripheral tolerance that are responsible for the T effector/T regulatory cell dysbalance in older age in general and in AS and RA in particular. 3. Translation of the results obtained in (a) and (b) into practical application for the prevention and treatment of AS and RA by appropriate vaccines. For all partners, important technical platforms will be available, including unique transgenic and knockout mouse strains, sophisticated models for in vitro and in vivo transfection of dendritic cells (DCs) and a well established Functional Genomics Facility.

Aufforderung zur Vorschlagseinreichung

FP7-HEALTH-2007-A
Andere Projekte für diesen Aufruf anzeigen

Koordinator

MEDIZINISCHE UNIVERSITAT INNSBRUCK
Adresse
Christoph Probst Platz 1
6020 Innsbruck
Österreich

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Aktivitätstyp
Higher or Secondary Education Establishments
Kontakt Verwaltung
Georg Wick (Prof.)
EU-Beitrag
€ 1 224 500

Beteiligte (9)

KANTONSSPITAL ST. GALLEN
Schweiz
EU-Beitrag
€ 928 000
Adresse
Rorschacherstrasse 95
9007 St. Gallen

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Aktivitätstyp
Research Organisations
Kontakt Verwaltung
Burkhard Ludewig (Dr.)
KAROLINSKA INSTITUTET
Schweden
EU-Beitrag
€ 1 042 000
Adresse
Nobels Vag 5
17177 Stockholm

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Aktivitätstyp
Higher or Secondary Education Establishments
Kontakt Verwaltung
Cecilia Tilly (Ms.)
DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG
Deutschland
EU-Beitrag
€ 676 240
Adresse
Im Neuenheimer Feld 280
69120 Heidelberg

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Aktivitätstyp
Research Organisations
Kontakt Verwaltung
Bettina Crispin (Ms.)
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
Frankreich
EU-Beitrag
€ 655 600
Adresse
Rue De Tolbiac 101
75654 Paris

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Aktivitätstyp
Research Organisations
Kontakt Verwaltung
Marianne Cottet (Ms.)
FONDAZIONE HUMANITAS PER LA RICERCA
Italien
EU-Beitrag
€ 786 000
Adresse
Via Manzoni
20089 Rozzano

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Aktivitätstyp
Research Organisations
Kontakt Verwaltung
Danilo Petroni (Dr.)
UNIVERSITEIT UTRECHT
Niederlande
EU-Beitrag
€ 803 591
Adresse
Heidelberglaan 8
3584 CS Utrecht

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Aktivitätstyp
Higher or Secondary Education Establishments
Kontakt Verwaltung
Alexandra Dijk (Dr.)
UNIVERSITA' DEGLI STUDI DI MILANO-BICOCCA
Italien
EU-Beitrag
€ 565 000
Adresse
Piazza Dell'ateneo Nuovo 1
20126 Milano

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Aktivitätstyp
Higher or Secondary Education Establishments
Kontakt Verwaltung
Anastasia Sguera (Dr.)
FUNCTIONAL GENOMICS CONSORTIUM
Italien
EU-Beitrag
€ 806 000
Adresse
Piazza Della Scienza 2 Universita Degli Studi Milano
20126 Milan

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Aktivitätstyp
Research Organisations
Kontakt Verwaltung
Paola Castagnoli (Prof.)
CENTER OF EXCELLENCE IN MEDICINE AND IT GMBH
Österreich
EU-Beitrag
€ 250 000
Adresse
Karl Kapferer Strasse 5
6020 Innsbruck

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Aktivitätstyp
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Kontakt Verwaltung
Stefan Masser (Mr.)