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Fighting osteoporosis by blocking nucleotides: purinergic signalling in bone formation and homeostasis

Objective

"Osteoporosis is a disabling disease and the incidence is expected to increase significantly over the next decades due to an increase in the elderly population. This will lead to an enormous economical burden both in the European Union and in the rest of the world. Osteoporosis should be treated early in order to prevent the bone fractures related to the disease, and a number of anti-resorptive treatments exist that can reduce the loss of bone. However, the possibilities of regaining already lost bone are limited, as only one anabolic treatment option (parathyroid hormone (PTH) )is available on the market. In most countries PTH is restricted to the most severe cases of osteoporosis with multiple fractures. Thus new anabolic treatment options for osteoporosis are highly warranted. Purinergic signalling, where nucleotides such as ATP act as extracellular signalling molecules, is a rapidly expanding field. The purinergic system has plays a central role in bone physiology, and bone deposition and resorption are finely tuned by extracellular nucleotides. Furthermore, the ""purinergic system"" is now believed to be one of the main transducing pathways of mechanical stimulation, a stimulus that is highly anabolic to bone. The overall aim of the proposal is to definitively prove the role of ATP and purinergic receptor signalling in the control of bone formation and homeostasis, thereby proving the potential of the system as a target for the development of new anabolic treatment regimens for osteoporosis. The aim will be addressed by examining the role of ATP as a signalling molecule in bone, the pathways and purinergic receptors involved in the signalling and their role in bone formation and homeostasis in vitro. Furthermore, translational studies in in vivo P2 receptor knock out mice will be used to show the role of the signalling pathways on bone, as well as small-scale clinical proof-of-concept studies to prove the potential of the system in targeting osteoporosis."

Field of science

  • /social sciences/economics and business/business and management/commerce
  • /medical and health sciences/basic medicine/physiology/homeostasis
  • /natural sciences/biological sciences/genetics and heredity/nucleotide
  • /medical and health sciences/basic medicine/physiology

Call for proposal

FP7-HEALTH-2007-A
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

REGION HOVEDSTADEN
Address
Kongens Vaenge 2
3400 Hillerod
Denmark
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
EU contribution
€ 483 800
Administrative Contact
Jesper Thyge Johansen (Mr.)

Participants (6)

University College London
United Kingdom
EU contribution
€ 416 912
Address
Gower Street
WC1E 6BT London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Michael Browne (Dr.)
UNIVERSITEIT MAASTRICHT
Netherlands
EU contribution
€ 450 440
Address
Minderbroedersberg 4-6
6200 MD Maastricht
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Joseph I H Janssen (Dr.)
UNIVERSITA DEGLI STUDI DI FERRARA
Italy
EU contribution
€ 292 800
Address
Via Ariosto 35
44121 Ferrara
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Francesco Di Virgilio (Prof.)
THE UNIVERSITY OF LIVERPOOL
United Kingdom
EU contribution
€ 317 936
Address
Brownlow Hill 765 Foundation Building
L69 7ZX Liverpool
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Colin Cooper (Mr.)
THE UNIVERSITY OF SHEFFIELD
United Kingdom
EU contribution
€ 673 594
Address
Firth Court Western Bank
S10 2TN Sheffield
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Gill Wells (Mr.)
UNIVERSITE LIBRE DE BRUXELLES
Belgium
EU contribution
€ 363 200
Address
Avenue Franklin Roosevelt 50
1050 Bruxelles
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Jean-Marie Boeynaems (Prof.)