Final Report Summary - CHROMOSOME STABILITY (Coordination of DNA replication and DNA repair at single-forks: the role of the Smc5-Smc6 complex in replication fork stalling and resumption)
We also made an unexpected discovery while studying damaged replication forks. We developed our observation and were able to show that during mitosis there is an alteration of the DNA winding status that requires attachments of the spindles to kinetochores and the Condensin complex that promotes decatenation by topoisomerase II.