Obiettivo Disruption of hormonal signalling in fetal life can irreversibly affect human development and reproductive health at a later age. Of considerable concern in Europe is a decline in male semen quality and a high prevalence of congenital malformations and hormone-dependent cancers. Although it appears plausible that environmental chemicals with endocrine activity may be involved in the causation of these disorders, there is no evidence for adverse effects of individual substances at relevant human exposure levels. However, there are indications that combinations of chemicals play a cumulative role. CONTAMED aims to explore the hypothesis that combined exposure to endocrine disrupting chemicals in fetal life may lead to adverse delayed impacts on human reproductive health. To achieve this goal, CONTAMED will combine epidemiological approaches with laboratory science. The work plan for CONTAMED is organised in three major strands focusing on human studies, animal models and in vitro assays including metabolomics. The project will deliver new epidemiological insights into associations between cumulative exposure and reproductive health, improved toxicological risk assessment for the anticipation of reproductive effects of chemicals, validated biomarkers for cumulative exposures and new mechanistic information about the ways in which chemicals may disrupt sexual differentiation during development. CONTAMED will provide the knowledge necessary to set the scene for Europe-wide human health impact studies of cumulative exposures to endocrine active chemicals and their possible role in the deterioration of reproductive health in Europe. Finally, the project will analyze the implications of new scientific findings for the European Environment and Health Action Plan and the Community Strategy for Endocrine Disrupters. Campo scientifico medical and health scienceshealth sciencessocial biomedical sciencessexual healthmedical and health sciencesclinical medicineoncologynatural sciencesearth and related environmental sciencesenvironmental sciencespollution Parole chiave cumulative exposure human reproductive health Programma(i) FP7-ENVIRONMENT - Specific Programme "Cooperation": Environment (including Climate Change) Argomento(i) ENV.2007.1.2.1.2. - Environmental factors and their impact on reproduction and development Invito a presentare proposte FP7-ENV-2007-1 Vedi altri progetti per questo bando Meccanismo di finanziamento CP-FP - Small or medium-scale focused research project Coordinatore BRUNEL UNIVERSITY LONDON Contributo UE € 323 304,59 Indirizzo KINGSTON LANE UB8 3PH Uxbridge Regno Unito Mostra sulla mappa Regione London Outer London — West and North West Harrow and Hillingdon Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Andreas Kortenkamp (Prof.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato Partecipanti (8) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto DANMARKS TEKNISKE UNIVERSITET Danimarca Contributo UE € 603 129,20 Indirizzo ANKER ENGELUNDS VEJ 101 2800 Kongens Lyngby Mostra sulla mappa Regione Danmark Hovedstaden Københavns omegn Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Ulla Hass (Dr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato THE UNIVERSITY OF SUSSEX Regno Unito Contributo UE € 499 990,80 Indirizzo SUSSEX HOUSE FALMER BN1 9RH Brighton Mostra sulla mappa Regione South East (England) Surrey, East and West Sussex Brighton and Hove Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Elizabeth Hill (Dr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato UNIVERSIDAD DE GRANADA Spagna Contributo UE € 399 072,80 Indirizzo CUESTA DEL HOSPICIO SN 18071 Granada Mostra sulla mappa Regione Sur Andalucía Granada Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Nicolas Olea Serrano (Prof.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM Paesi Bassi Contributo UE € 323 060,40 Indirizzo DR MOLEWATERPLEIN 40 3015 GD Rotterdam Mostra sulla mappa Regione West-Nederland Zuid-Holland Groot-Rijnmond Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Alex Burdorf (Dr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato GREEN TOX GMBH Svizzera Contributo UE € 499 814,00 Indirizzo LANGACKERSTRASSE 49 8057 Zurich Mostra sulla mappa Regione Schweiz/Suisse/Svizzera Zürich Zürich Tipo di attività Private for-profit entities (excluding Higher or Secondary Education Establishments) Contatto amministrativo Walter Lichtensteiger (Prof.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato FAUST UND BACKHAUS ENVIRONMENTAL CONSULTING GBR Germania Contributo UE € 150 000,00 Indirizzo FAHRENHEITSTRASSE 1 28359 BREMEN Mostra sulla mappa Tipo di attività Private for-profit entities (excluding Higher or Secondary Education Establishments) Contatto amministrativo Michael Faust (Dr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato UNIVERSITY OF BRISTOL Regno Unito Contributo UE € 290 734,80 Indirizzo BEACON HOUSE QUEENS ROAD BS8 1QU Bristol Mostra sulla mappa Regione South West (England) Gloucestershire, Wiltshire and Bristol/Bath area Bristol, City of Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Vince Boyle (Mr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato THE SCHOOL OF PHARMACY, UNIVERSITY OF LONDON Partecipazione conclusa Regno Unito Contributo UE € 405 245,41 Indirizzo Brunswick Square 29-39 WC1N 1AX LONDON Mostra sulla mappa Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Andreas Kortenkamp (Prof.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato