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Kainate receptors and neuronal growth

Obiettivo

This project sets out to employ emergent techniques and state-of-the-art technology to investigate the cellular and molecular mechanisms underlying the trafficking and synaptic expression of the kainate receptor subunit GluR6 in developing hippocampal newer ones. Briefly, a series of chimeras of KAR subunits and new fluorophores including pH-sensitive GFP (pHluorin) and photoactivatable-GFP will be constructed, expressed in neurones by viral infection protocols and imaged using confocal microscopy to determine how kainate receptors behave in living hippocampal neurones and what pathways are involved in their trafficking. This questions are important because kainate receptors in general, and GluR6 in particular, have been implicated in neuronal development an d synapse stabilisation. Therefore, increased understanding of the processes that regulate these subunits will inform work on normal neuronal development and plasticity as well neuropathology associated with certain neurodegenerative conditions such as Al zheimer's disease.

Campo scientifico (EuroSciVoc)

Argomento(i)

Invito a presentare proposte

FP6-2004-MOBILITY-7
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Meccanismo di finanziamento

IIF - Marie Curie actions-Incoming International Fellowships

Coordinatore

UNIVERSITY OF BRISTOL
Contributo UE
Nessun dato
Costo totale
Nessun dato