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Functional assays for membrane protein on nanostructured supports

Objectif

More than 50% of all drug targets are membrane proteins; new research tools to screen function of membrane drug targets are therefore expected to open up new avenues for original drug development. The proposed project addresses the need of the pharmaceutical industry for new technologies for reliable and efficient screening of membrane proteins as drug targets. Most critical current aspects of membrane protein assays are (a) the lack of reliable procedures to immobilize membrane proteins on sensor surfaces in a format suitable for label-free high-throughput screening of drug candidates; (b) the need for downscaling assay formats to accelerate functional screening; and (c) the feasibility of reading out the diverse functions of membrane proteins. The partners – with highly complementary expertise and experience of working together – will develop platforms for functional membrane protein assays by integration of the most recently gained knowledge and techniques. The key concepts of the platforms include (a) exploitation of nanoporous substrates to enhance the stability of supported proteolipid membranes and their integration in a sensor chip format; (b) nanoscale surface modifications for directed self-assembly of proteolipid structures on chip; and (c) self-assembly of proteolipid membranes onto nano-sized sensor structures from proteoliposomes, and demonstration of the functionality in quantitative drug candidate screening assays suitable for commercial applications. The project is expected to make a substantial contribution to (a) improved understanding of lipid membrane and membrane protein interaction with designed nanoenvironments; (b) development of prototype products and intellectual property related to membrane protein sorting and handling; (c) new compounds for functionalization of biosensor applications; (d) cost-effective array-based concepts for nanoplasmonic and electrochemical sensing; and (e) functional assays for membrane protein drug targets.

Appel à propositions

FP7-NMP-2007-SMALL-1
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Coordinateur

EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
Adresse
Raemistrasse 101
8092 Zuerich
Suisse

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Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Janos Vörös (Mr.)
Contribution de l’UE
€ 746 920

Participants (13)

PAUL SCHERRER INSTITUT
Suisse
Contribution de l’UE
€ 312 278
Adresse
Forschungstrasse 111
5232 Villigen Psi

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Type d’activité
Research Organisations
Contact administratif
Irene Walthert (Ms.)
CHALMERS TEKNISKA HOGSKOLA AB
Suède
Contribution de l’UE
€ 515 139
Adresse
-
412 96 Goteborg

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Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Annika Hofling (Ms.)
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
Allemagne
Contribution de l’UE
€ 426 167
Adresse
Hofgartenstrasse 8
80539 Munchen

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Type d’activité
Research Organisations
Contact administratif
Udo Schreiner (Mr.)
UNIVERSITE BORDEAUX I
France
Contribution de l’UE
€ 389 100
Adresse
351 Cours De La Liberation
33405 Talence

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Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Didier Lassaque (Mr.)
EOTVOS LORAND TUDOMANYEGYETEM
Hongrie
Contribution de l’UE
€ 98 160
Adresse
Egyetem Ter 1-3
1053 Budapest

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Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Katalin Juhászné Huszty (Dr.)
UNIVERSITEIT TWENTE
Pays-Bas
Contribution de l’UE
€ 382 575
Adresse
Drienerlolaan 5
7522 NB Enschede

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Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Gyula Julius Vancso (Prof.)
LEISTER PROCESS TECHNOLOGIES*
Suisse
Contribution de l’UE
€ 278 160
Adresse
Galileo-strasse 10
6056 Kagiswil

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Type d’activité
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contact administratif
Marco Di Berardino (Dr.)
Layerlab AB
Suède
Contribution de l’UE
€ 137 099
Adresse
Stena Center 1d
412 92 Goteborg

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Type d’activité
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contact administratif
Torbjorn Pettersson (Mr.)
SuSoS AG
Suisse
Contribution de l’UE
€ 60 960
Adresse
Lagerstrasse 14
8600 Dubendorf

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Type d’activité
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contact administratif
Samuele Tosatti (Dr.)
Farfield Group Limited
United Kingdom
Contribution de l’UE
€ 190 320
Adresse
Farfield House, Southmere Court, Electra Way, Crewe Business Park
CWI 6GU Crewe

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Type d’activité
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contact administratif
Louise Madden (Ms.)
MIKROVAKUUM MIKROELEKTRONIKAI ES VAKUUMTECHNIKAL KFT
Hongrie
Contribution de l’UE
€ 157 920
Adresse
Kerekgyarto U 10
1147 Budapest

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Type d’activité
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contact administratif
Istvan Szendro (Mr.)
HYDROGENE AB
Suède
Contribution de l’UE
€ 165 000
Adresse
Martens Falad 102
225 92 Lund

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Type d’activité
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contact administratif
Per Kjellbom (Prof.)
F. HOFFMANN-LA ROCHE AG
Suisse
Contribution de l’UE
€ 80 300
Adresse
Grenzacherstrasse 124
4070 Basel

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Type d’activité
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contact administratif
Michael Hennig (Dr.)