Objective Vascular atherosclerotic plaque remodelling leading to rupture is responsible for about half of the total deaths in the European Union. Upon disruption of the atherosclerotic plaque, the highly trombogenic plaque content is exposed to the circulating blood leading to thrombus formation and subsequent occlusion of the artery. When plaque rupture occurs f.e. in a coronary artery this will lead to a myocardial infarction often followed by death.The mechanisms of plaque remodelling leading to destabilization and rupture are poorly understood. Since appropriate animal models for plaque rupture are lacking, we use as a starting point a large number (~600) of well characterized carotid endarterectomy specimen from patients that are well documented and undergo a follow up. We combine this Dutch tissue bank with state of the art proteomics approaches present in Singapore.This combination will use the classical approach to screen for proteins that differ between stable fibrous and unstable inflammatory plaques and between stable and ruptured plaque (Objective 1). Next to this approach, we will screen for proteins that differ between for proteins that differ between patients that had a cardiovascular event and control patients, an approach that can redefine the definition of the vulnerable plaque (Objective 2). The differential expression of the proteins will be validated in a large population allowing correction for confounding (Objective 3).After the proteomics approach and return to the Netherlands, we will investigate t he role of the differentially expressed proteins as a blood marker and its function. The research performed in the frame of this project will increase the global understanding of atherosclerosis and largely impact the overall management of this pathology as well as the development of novel therapeutic strategies and biomarkers. Fields of science natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsproteomicsmedical and health sciencesclinical medicinecardiologycardiovascular diseasesarteriosclerosismedical and health sciencesbasic medicinepathologymedical and health sciencesbasic medicineneurologystrokemedical and health scienceshealth sciencesnutritionobesity Keywords Atherosclerosis Plaque Vulnerability Rupture Programme(s) FP6-MOBILITY - Human resources and Mobility in the specific programme for research, technological development and demonstration "Structuring the European Research Area" under the Sixth Framework Programme 2002-2006 Topic(s) MOBILITY-2.2 - Marie Curie Outgoing International Fellowships (OIF) Call for proposal FP6-2004-MOBILITY-6 See other projects for this call Funding Scheme OIF - Marie Curie actions-Outgoing International Fellowships Coordinator INTERUNIVERSITY CARDIOLOGY INSTITUTE OF THE NETHERLANDS/ROYAL DUTCH ACADEMY OF ART AND SCIENCES Address Catherijnesingel 52 Utrecht Netherlands See on map Links Website Opens in new window EU contribution € 0,00 Participants (1) Sort alphabetically Sort by EU Contribution Expand all Collapse all GENOME INSTITUTE SINGAPORE Singapore EU contribution € 0,00 Address Genome #02-01, 60 biopolis street Singapore See on map
