Objective
Vascular atherosclerotic plaque remodelling leading to rupture is responsible for about half of the total deaths in the European Union. Upon disruption of the atherosclerotic plaque, the highly trombogenic plaque content is exposed to the circulating blood leading to thrombus formation and subsequent occlusion of the artery. When plaque rupture occurs f.e. in a coronary artery this will lead to a myocardial infarction often followed by death.
The mechanisms of plaque remodelling leading to destabilization and rupture are poorly understood. Since appropriate animal models for plaque rupture are lacking, we use as a starting point a large number (~600) of well characterized carotid endarterectomy specimen from patients that are well documented and undergo a follow up. We combine this Dutch tissue bank with state of the art proteomics approaches present in Singapore.
This combination will use the classical approach to screen for proteins that differ between stable fibrous and unstable inflammatory plaques and between stable and ruptured plaque (Objective 1). Next to this approach, we will screen for proteins that differ between for proteins that differ between patients that had a cardiovascular event and control patients, an approach that can redefine the definition of the vulnerable plaque (Objective 2). The differential expression of the proteins will be validated in a large population allowing correction for confounding (Objective 3).
After the proteomics approach and return to the Netherlands, we will investigate t he role of the differentially expressed proteins as a blood marker and its function. The research performed in the frame of this project will increase the global understanding of atherosclerosis and largely impact the overall management of this pathology as well as the development of novel therapeutic strategies and biomarkers.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine cardiology cardiovascular diseases arteriosclerosis
- medical and health sciences clinical medicine endocrinology diabetes
- medical and health sciences basic medicine pathology
- medical and health sciences basic medicine neurology stroke
- medical and health sciences health sciences nutrition obesity
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2004-MOBILITY-6
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
OIF - Marie Curie actions-Outgoing International Fellowships
Coordinator
UTRECHT
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.