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The role of adipose tissue in obesity: beta cell crosstalk

Objective

Obesity is an emerging threat to European health and more effective and sustainable therapies are urgently needed to tackle it. Adipose tissue is acknowledged to be a key player in lipid metabolism and plays multiple roles in regulating whole-body physiology, through the secretion of hormones called adipokines. However adipokine secretion and its mediated crosstalk with other tissues are not well defined. This knowledge gap must be addressed to identify and exploit new therapeutic targets for reducing or reversing obesity and its complications. This is ADIBET's aim; to develop new knowledge and identify druggable targets by unraveling the molecular basis of adipose tissue regulation and crosstalk in vivo. ADIBET will take on 2 complementary tasks: explore adipokine-mediated crosstalk with beta cells and describe the effects of obesity on differential adipocyte function and secretion pattern. New knowledge in this area is a pre-requisite to developing new treatments for diabetes and can most effectively be delivered by industry-academic partnership. ADIBET combines 2 prestigious Academic partners and 2 promising European SMEs who will be working hand in hand, to forge a lasting partnership which will focus European academic research into the European market. ADIBET is a multidisciplinary scientific and training programme. The young or experienced researchers will acquire a broad range of skills from communication to functional omics, and from mathematical and computational modeling to intellectual property rights. The ADIBET partnership brings together state of the art tools, resources and know-how with a clearly structured human resource exchange programme to ensure efficient intersectorial transfer of knowledge. Thus, ADIBET is an unprecedented opportunity to yield new knowledge of obesity pathophysiology, to identify new drug targets and to leave a lasting technical and knowledge platform on which to build European research in the coming decade.

Call for proposal

FP7-PEOPLE-2007-3-1-IAPP
See other projects for this call

Funding Scheme

MC-IAPP - Industry-Academia Partnerships and Pathways (IAPP)

Coordinator

CONSORCI INSTITUT D'INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER
Address
Calle Rossello 149 Puerta Bjs
08036 Barcelona
Spain
Activity type
Other
EU contribution
€ 465 597
Administrative Contact
Ramon Gomis (Prof.)

Participants (3)

THE UNIVERSITY OF WARWICK
United Kingdom
EU contribution
€ 500 557
Address
Kirby Corner Road - University House
CV4 8UW Coventry
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Kate Hughes (Ms.)
GenoSyst Ltd.
Finland
EU contribution
€ 318 597
Address
Itainen Pitkakatu 4B
20520 Turku
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Attila Gyenesei (Dr.)
OBETHERAPY BIOTECHNOLOGY SAS
France
EU contribution
€ 184 174
Address
Rue Pierre Fontaine 4
91000 Evry
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Itzik Harosh (Dr.)