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The role of adipose tissue in obesity: beta cell crosstalk

Obiettivo

Obesity is an emerging threat to European health and more effective and sustainable therapies are urgently needed to tackle it. Adipose tissue is acknowledged to be a key player in lipid metabolism and plays multiple roles in regulating whole-body physiology, through the secretion of hormones called adipokines. However adipokine secretion and its mediated crosstalk with other tissues are not well defined. This knowledge gap must be addressed to identify and exploit new therapeutic targets for reducing or reversing obesity and its complications. This is ADIBET's aim; to develop new knowledge and identify druggable targets by unraveling the molecular basis of adipose tissue regulation and crosstalk in vivo. ADIBET will take on 2 complementary tasks: explore adipokine-mediated crosstalk with beta cells and describe the effects of obesity on differential adipocyte function and secretion pattern. New knowledge in this area is a pre-requisite to developing new treatments for diabetes and can most effectively be delivered by industry-academic partnership. ADIBET combines 2 prestigious Academic partners and 2 promising European SMEs who will be working hand in hand, to forge a lasting partnership which will focus European academic research into the European market. ADIBET is a multidisciplinary scientific and training programme. The young or experienced researchers will acquire a broad range of skills from communication to functional omics, and from mathematical and computational modeling to intellectual property rights. The ADIBET partnership brings together state of the art tools, resources and know-how with a clearly structured human resource exchange programme to ensure efficient intersectorial transfer of knowledge. Thus, ADIBET is an unprecedented opportunity to yield new knowledge of obesity pathophysiology, to identify new drug targets and to leave a lasting technical and knowledge platform on which to build European research in the coming decade.

Invito a presentare proposte

FP7-PEOPLE-2007-3-1-IAPP
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Coordinatore

CONSORCI INSTITUT D'INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER
Indirizzo
Calle Rossello 149 Puerta Bjs
08036 Barcelona
Spagna
Tipo di attività
Other
Contributo UE
€ 465 597
Contatto amministrativo
Ramon Gomis (Prof.)

Partecipanti (3)

THE UNIVERSITY OF WARWICK
United Kingdom
Contributo UE
€ 500 557
Indirizzo
Kirby Corner Road - University House
CV4 8UW Coventry
Tipo di attività
Higher or Secondary Education Establishments
Contatto amministrativo
Kate Hughes (Ms.)
GenoSyst Ltd.
Finlandia
Contributo UE
€ 318 597
Indirizzo
Itainen Pitkakatu 4B
20520 Turku
Tipo di attività
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contatto amministrativo
Attila Gyenesei (Dr.)
OBETHERAPY BIOTECHNOLOGY SAS
Francia
Contributo UE
€ 184 174
Indirizzo
Rue Pierre Fontaine 4
91000 Evry
Tipo di attività
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contatto amministrativo
Itzik Harosh (Dr.)