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Multifunctional DNA light-switches: sensors and devices

Objective

Photoactive mono- and oligonuclear transition metal complexes containing DNA intercalative ligands will be synthesized. In the latter case, both homo- and heterometallic complexes will be synthesized. The photophysical properties of the complexes will be exploited to produce a number of outcomes: prototypical sensors for DNA sequences and/or structures that will produce a luminescent output on DNA binding, tools for investigating DNA/substrate binding events and the photophysical/electronic properties of DNA. The synthesis of multi-functional probes will also be investigated; e.g. DNA light-switches that also cleave DNA (directly OR through singlet oxygen sensitizing) and/or display cytotoxicity. To fully understand the properties of the new systems and their interaction with DNA studies will encompass a wide spectrum of techniques from time resolved optical spectroscopy, to calorimetry and in cellulo studies.

Field of science

  • /natural sciences/chemical sciences/analytical chemistry/spectroscopy
  • /natural sciences/chemical sciences/analytical chemistry/calorimetry

Call for proposal

FP7-PEOPLE-2007-4-2-IIF
See other projects for this call

Funding Scheme

MC-IIF - International Incoming Fellowships (IIF)

Coordinator

THE UNIVERSITY OF SHEFFIELD
Address
Firth Court Western Bank
S10 2TN Sheffield
United Kingdom
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 169 957,94
Administrative Contact
Gill Wells (Ms.)