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Multifunctional DNA light-switches: sensors and devices

Obiettivo

Photoactive mono- and oligonuclear transition metal complexes containing DNA intercalative ligands will be synthesized. In the latter case, both homo- and heterometallic complexes will be synthesized. The photophysical properties of the complexes will be exploited to produce a number of outcomes: prototypical sensors for DNA sequences and/or structures that will produce a luminescent output on DNA binding, tools for investigating DNA/substrate binding events and the photophysical/electronic properties of DNA. The synthesis of multi-functional probes will also be investigated; e.g. DNA light-switches that also cleave DNA (directly OR through singlet oxygen sensitizing) and/or display cytotoxicity. To fully understand the properties of the new systems and their interaction with DNA studies will encompass a wide spectrum of techniques from time resolved optical spectroscopy, to calorimetry and in cellulo studies.

Campo scientifico (EuroSciVoc)

Parole chiave

Argomento(i)

Invito a presentare proposte

FP7-PEOPLE-2007-4-2-IIF
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Meccanismo di finanziamento

MC-IIF - International Incoming Fellowships (IIF)

Coordinatore

THE UNIVERSITY OF SHEFFIELD
Contributo UE
€ 169 957,94
Indirizzo
FIRTH COURT WESTERN BANK
S10 2TN SHEFFIELD
Regno Unito
Regione
Yorkshire and the Humber South Yorkshire Sheffield
Tipo di attività
Higher or Secondary Education Establishments
Collegamenti
Costo totale
Nessun dato