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Multifunctional DNA light-switches: sensors and devices

Objetivo

Photoactive mono- and oligonuclear transition metal complexes containing DNA intercalative ligands will be synthesized. In the latter case, both homo- and heterometallic complexes will be synthesized. The photophysical properties of the complexes will be exploited to produce a number of outcomes: prototypical sensors for DNA sequences and/or structures that will produce a luminescent output on DNA binding, tools for investigating DNA/substrate binding events and the photophysical/electronic properties of DNA. The synthesis of multi-functional probes will also be investigated; e.g. DNA light-switches that also cleave DNA (directly OR through singlet oxygen sensitizing) and/or display cytotoxicity. To fully understand the properties of the new systems and their interaction with DNA studies will encompass a wide spectrum of techniques from time resolved optical spectroscopy, to calorimetry and in cellulo studies.

Ámbito científico (EuroSciVoc)

Palabras clave

Programa(s)

Tema(s)

Convocatoria de propuestas

FP7-PEOPLE-2007-4-2-IIF
Consulte otros proyectos de esta convocatoria

Régimen de financiación

MC-IIF - International Incoming Fellowships (IIF)

Coordinador

THE UNIVERSITY OF SHEFFIELD
Aportación de la UE
€ 169 957,94
Dirección
FIRTH COURT WESTERN BANK
S10 2TN SHEFFIELD
Reino Unido
Región
Yorkshire and the Humber South Yorkshire Sheffield
Tipo de actividad
Higher or Secondary Education Establishments
Enlaces
Coste total
Sin datos