Objective
Tumors of the upper aerodigestive tract (lung, head and neck, esophageal) are the major cause of cancer related deaths in Europe, with an estimated 436,700 deaths in 2006. No screening for early detection has proven effective and most patients are diagnosed with incurable disease. Squamous cell carcinoma (SCC) is a common histologic type developing via a series of stages from normal epithelium, through metaplasia to dysplasia, then carcinoma in situ and finally invasive cancer. Notably, the majority of the preinvasive lesions reverts back to normal or do not progress. The identification of molecular markers predictive of progression from preinvasive to invasive cancer is the key to develop successful screening tools. Genomic alterations are particularly suitable molecular markers of cancer. The most common genomic abnormality in SCC is gene amplification on chromosome 3q. Despite several candidate oncogene(s) having been identified in this region, due to limits of resolution of current techniques, the minuscule amount of tissue from preinvasive lesions and the fact that most studies were done before the human genome sequence was available, the relevance of these genes in the etiology of SCC is controversial and the precise target(s) of 3q amplification remains ill defined. This project will characterize the 3q amplified region (amplicon) in preinvasive lesions that precede head and neck cancer and lung cancer using molecular copy number counting, a new technique based on PCR, which requires small amounts of DNA and evaluates many genomic loci simultaneously. Mapping of 3q amplicon will be performed on archival and prospectively collected biopsies. We expect to better define the candidate oncogene(s) in this region. These markers, acting as surrogates of pre-cancer, could allow the development of tools to select subjects at higher risk, who might benefit from intense surveillance and/or early treatment and could also be used as endpoints in cancer-prevention trials.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine oncology lung cancer
- medical and health sciences clinical medicine oncology skin cancer squamous cell carcinoma
- medical and health sciences clinical medicine oncology head and neck cancer
- natural sciences biological sciences genetics chromosomes
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2007-2-1-IEF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
LS2 9JT Leeds
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.