Obiettivo Anemias and erythroid malignancies caused by impaired formation of erythrocytes (red blood cells) are common disorders. These diseases have a severe impact on the quality of life of the patients. It is essential to unravel the molecular mechanisms underlying erythropoiesis (the development of red blood cells) to be able to fully understand the etiology of these diseases and to devise novel treatments. The most important part of understanding the molecular mechanisms of erythropoiesis is the unraveling of its transcription factor network and studying how this network responds to outside signals. I propose to analyze the function and dynamics of this network through a study of the factors that are part of the Ldb1/Gata1 complex, and in particular the function of the LMO4 protein. Campo scientifico natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsmedical and health sciencesclinical medicinehematology Parole chiave Development Haematopoiesis Haematopoietic stem cells Health sciences LMO4 Transcription factor complexes Programma(i) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Argomento(i) PEOPLE-2007-2-1.IEF - Marie Curie Action: "Intra-European Fellowships for Career Development" Invito a presentare proposte FP7-PEOPLE-2007-2-1-IEF Vedi altri progetti per questo bando Meccanismo di finanziamento MC-IEF - Intra-European Fellowships (IEF) Coordinatore ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM Contributo UE € 165 996,12 Indirizzo DR MOLEWATERPLEIN 40 3015 GD Rotterdam Paesi Bassi Mostra sulla mappa Regione West-Nederland Zuid-Holland Groot-Rijnmond Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Riet Van Zeijl (Ms.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato