Oxasilacyclohexenes -Chiral Scaffolds in Ruthenium Catalysed Tandem Synthesis

Project Information

OCSRCTS

Grant agreement ID: 22153

Project closed

Start date 1 September 2005

End date 31 August 2008

Funded under

• Human resources and Mobility in the specific programme for research, technological development and demonstration "Structuring the European Research Area" under the Sixth Framework Programme 2002-2006

Total cost No data

EU contribution No data

Coordinated by

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom

Objective

Oxasilacyclohexenes are synthetic intermediates with untapped potential; they combine the tuneable reactivity of substituted vinylsilanes with that of cyclic conformational rigidity. This proposal details the ruthenium catalysed formation of chiral oxasila cycle intermediates with pendant functionality capable of tandem reactions under residual Ru(II) Lewis acidic conditions. The first section focuses on the development of a research programme to optimise reactivity and selectivity in the synthesis of chiral oxasilacycle scaffolds and their ability to participate in tandem reactions. The second section will give examples of the application of this methodology in the synthesis of biologically interesting compounds.

Fields of science

Not validated

• natural sciences › chemical sciences › inorganic chemistry › transition metals

Keywords

• Asymmetric Catalysis with Transition Metals

Programme(s)

• FP6-MOBILITY - Human resources and Mobility in the specific programme for research, technological development and demonstration "Structuring the European Research Area" under the Sixth Framework Programme 2002-2006

Topic(s)

• MOBILITY-2.2 - Marie Curie Outgoing International Fellowships (OIF)

Call for proposal

FP6-2004-MOBILITY-6
See other projects for this call

Funding Scheme

OIF - Marie Curie actions-Outgoing International Fellowships

Coordinator

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE

• EU contribution: No data
• Address: United Kingdom
• Total cost: No data

Participants (1)

LELAND STANFORD JR. MEMORIAL UNIVERSITY

United States

• EU contribution: No data
• Total cost: No data