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Oxasilacyclohexenes -Chiral Scaffolds in Ruthenium Catalysed Tandem Synthesis

Objective

Oxasilacyclohexenes are synthetic intermediates with untapped potential; they combine the tuneable reactivity of substituted vinylsilanes with that of cyclic conformational rigidity. This proposal details the ruthenium catalysed formation of chiral oxasila cycle intermediates with pendant functionality capable of tandem reactions under residual Ru(II) Lewis acidic conditions. The first section focuses on the development of a research programme to optimise reactivity and selectivity in the synthesis of chiral oxasilacycle scaffolds and their ability to participate in tandem reactions. The second section will give examples of the application of this methodology in the synthesis of biologically interesting compounds.

Call for proposal

FP6-2004-MOBILITY-6
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Coordinator

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE

Participants (1)

LELAND STANFORD JR. MEMORIAL UNIVERSITY
United States