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Oxasilacyclohexenes -Chiral Scaffolds in Ruthenium Catalysed Tandem Synthesis

Objectif

Oxasilacyclohexenes are synthetic intermediates with untapped potential; they combine the tuneable reactivity of substituted vinylsilanes with that of cyclic conformational rigidity. This proposal details the ruthenium catalysed formation of chiral oxasila cycle intermediates with pendant functionality capable of tandem reactions under residual Ru(II) Lewis acidic conditions. The first section focuses on the development of a research programme to optimise reactivity and selectivity in the synthesis of chiral oxasilacycle scaffolds and their ability to participate in tandem reactions. The second section will give examples of the application of this methodology in the synthesis of biologically interesting compounds.

Champ scientifique (EuroSciVoc)

Mots‑clés

Thème(s)

Appel à propositions

FP6-2004-MOBILITY-6
Voir d’autres projets de cet appel

Régime de financement

OIF - Marie Curie actions-Outgoing International Fellowships

Coordinateur

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
Contribution de l’UE
Aucune donnée
Adresse


Royaume-Uni
Coût total
Aucune donnée

Participants (1)