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Advanced affinity tools and technologies for high throughput studies of the human proteome

Objective

High specificity affinity reagents (‘binders’) are essential probes for proteome research, enabling the detection and localisation of multiple proteins in tissues and fluids in health and disease, through the application of binder-based technologies (affinity proteomics). This proposal links the high throughput production of quality-controlled, recombinant binding molecules of different types (antibody fragments, engineered scaffolds, aptamers) with advanced applications (capture microarrays, multidimensional fluorescence imaging, single molecule detection, intracellular knockdown) in the analysis of human proteome targets. The partners are five established SMEs and five leading academic groups, each with a reputation for innovation, engaged in binder production and characterisation or protein detection technologies. The project will aim to resolve bottlenecks in high throughput binder production and application technologies, including cost, throughput, automation and quality. The linkage of production, quality control and applications will be exemplified by targeting kinases and other proteins involved in the TGF-beta and MAP kinase signal transduction pathways, implicated in many diseases and where the availability of high quality binding reagents is particularly needed and drug development is actively evolving. As well as potential products, it will provide the SMEs with opportunities to exemplify and improve their technologies for future exploitation in proteomics, diagnostics and therapeutics.

Field of science

  • /natural sciences/biological sciences/biochemistry/biomolecules/proteins/proteomics

Call for proposal

FP7-HEALTH-2007-B
See other projects for this call

Funding Scheme

CP-TP - Collaborative Project targeted to a special group (such as SMEs)

Coordinator

BABRAHAM BIOSCIENCE TECHNOLOGIES LIMITED
Address
Babraham Hall
CB22 3AT Cambridge
United Kingdom
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
EU contribution
€ 392 575
Administrative Contact
Rebecca Paxton (Ms.)

Participants (9)

BIAFFIN GMBH & CO KG
Germany
EU contribution
€ 389 000,40
Address
Heinrich Plett Strasse 40
34132 Kassel
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Bastian Zimmermann (Dr.)
Source Bioscience plc
United Kingdom
EU contribution
€ 177 000
Address
Orchard Place, Business Park 1
NG8 6PX Nottingham
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Cliff Murray (Dr.)
NAVINCI DIAGNOSTICS AB
Sweden
EU contribution
€ 487 600
Address
Uppsala University Bmc D11 Plan 1 Husargatan 3
752 37 Uppsala
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Mats Gullberg (Dr.)
DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG
Germany
EU contribution
€ 313 560
Address
Im Neuenheimer Feld 280
69120 Heidelberg
Activity type
Research Organisations
Administrative Contact
Bettina Crispin (Ms.)
TECHNISCHE UNIVERSITAET BRAUNSCHWEIG
Germany
EU contribution
€ 370 880
Address
Universitaetsplatz 2
38106 Braunschweig
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Stefan Duebel (Prof.)
UNIVERSITAET KASSEL
Germany
EU contribution
€ 234 657,60
Address
Monchebergstrasse 19
34125 Kassel
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Tim Scholze (Mr.)
UPPSALA UNIVERSITET
Sweden
EU contribution
€ 158 772
Address
Von Kraemers Alle 4
751 05 Uppsala
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Pirkko Boox (Ms.)
University of Zurich
Switzerland
EU contribution
€ 311 000
Address
Ramistrasse 71
8006 Zurich
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Andreas Plückthun (Prof.)
SOMALOGIC INC
United States
EU contribution
€ 153 000
Address
Wilderness Place 2945
80301 Boulder Colorado
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Scott Kothlow (Dr.)