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Stem Cell Expansion - Expansion and engraftment of haematopoietic and mesenchymal stem cells

Objectif

Serious disorders of the blood system, particularly malignant blood disorders and genetic diseases can be effectively treated by blood and marrow transplantation. Despite considerable success with this treatment modality during the last decades, lack of suitable donors, engraftment failure and graft versus host disease remain serious problems that need to be addressed. This project aims to address these issues through approaches that will allow expansion of human umbilical cord blood stem cells for transplantation using cytokines, developmental cues, newly identified stem cell regulators and chemicals that can activate internal stem cell regulators to stimulate self-renewal and proliferation of hematopoietic stem cells. Successful expansion of cord blood stem cells will increase the number of hematopoietic stem cells in cord blood samples to generate suitable donor samples for adult patients that die from their disease today due to lack of donors. Expansion of hematopoietic stem- and progenitor cells will also give more efficient early engraftment following transplantation and thereby reduce the frequency of morbidity and mortality due to insufficient engraftment. This will be accomplished through the identification of novel stem cell regulators and the use of known cytokines, developmental cues and chemicals that will stimulate stem cell expansion. Improvement in hematopoietic stem cell transplantation through co-transplantation of mesenchymal stem cells will also be investigated. Conditions for expansion of mesenchymal stem cells will be defined and subsets of more primitive and more mature mesenchymal stem cells will be identified. Mesenchymal stem cells will also be used to improve engraftment efficiency of the expanded hematopoietic cells and to reduce the frequency of graft versus host disease. The findings are expected to have a great impact on the treatment of serious blood disorders by blood and marrow transplantation in the future.

Appel à propositions

FP7-HEALTH-2007-B
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Coordinateur

LUNDS UNIVERSITET
Adresse
Paradisgatan 5c
22100 Lund
Suède

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Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Jens Forsberg (Dr.)
Contribution de l’UE
€ 942 696

Participants (7)

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom
Contribution de l’UE
€ 496 942,19
Adresse
Wellington Square University Offices
OX1 2JD Oxford

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Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Linda Polik (Ms.)
ACADEMISCH ZIEKENHUIS GRONINGEN
Pays-Bas
Contribution de l’UE
€ 406 404
Adresse
Hanzeplein 1
9713 GZ Groningen

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Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Jan Breeuwsma (Mr.)
ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS
France
Contribution de l’UE
€ 272 560
Adresse
3 Avenue Victoria
75004 Paris

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Type d’activité
Research Organisations
Contact administratif
Christian Nicolas (Mr.)
ACADEMISCH ZIEKENHUIS LEIDEN
Pays-Bas
Contribution de l’UE
€ 406 654
Adresse
Albinusdreef 2
2333 ZA Leiden

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Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Sonja Croes (Ms.)
MEDICAL RESEARCH COUNCIL

Participation terminée

United Kingdom
Contribution de l’UE
€ 90 669,76
Adresse
20 Park Crescent
W1B 1AL London

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Type d’activité
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Contact administratif
Anne-Marie Coriat (Dr.)
KUROS BIOSCIENCES BV
Pays-Bas
Contribution de l’UE
€ 160 038
Adresse
Professor Bronkhorstlaan 10 G 48
3723 MB Bilthoven

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Type d’activité
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contact administratif
Joost De Bruijn (Prof.)
UNIVERSITY COLLEGE LONDON
United Kingdom
Contribution de l’UE
€ 219 426,05
Adresse
Gower Street
WC1E 6BT London

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Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Greta Borg-Carbott (Ms.)