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Preventing community and nosocomial spread and infection with MRSA ST 398 - instruments for accelerated control and integrated risk management of antimicrobial resistance

Objective

Methicillin-resistant Staphylococcus aureus (MRSA) are of increasing concern both as community- and hospital-acquired pathogens. Since 2005, a specific clone, MRSA ST398 is spreading both in livestock populations and occupationally-exposed people resulting in human infection and disease in several EU Member States. The key objective of the PILGRIM project is to provide a range of novel control measures for the accelerated identification and control of emerging resistant bacteria. In order to achieve these we will undertake epidemiological and physiological studies of MRSA ST398 and use molecular approaches in well comparable animal models as well as humans in community and healthcare settings to 1) investigate/explore its biology and ecology, 2) identify and characterise factors determining the transmission pathways and risk from animal to human and between humans, 3) establish genetic differences, host-range and virulence of adhesive and non-adhesive strains as well as differences between ST398 and other MRSA, 3) identify specific genes for the development of new rapid tests to identify specific MRSA strains, 4) provide a Technology Testing Platform for developing and assessing decolonisation and environmental sanitation approaches, 5) integrate results in policy and practice guidelines. This project brings together clinical, genetic, microbiological and public health partners from 6 European countries, internationally renowned for their expertise in complementary ecosystems research. The two SME partners ensure the exploitation of results and the knowledge transfer, enabling associated companies to bring validated solutions to the market. The PILGRIM research will facilitate rapid and cost-effective measures to combat emerging resistant strains in order to prevent and eradicate community and nosocomial infections for better protection of citizens and patients in Europe and beyond.

Field of science

  • /medical and health sciences/health sciences/public and environmental health
  • /medical and health sciences/basic medicine/pharmacology and pharmacy/drug resistance/antibiotic resistance
  • /social sciences/sociology/governance/crisis management

Call for proposal

FP7-HEALTH-2007-B
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

THE ROYAL VETERINARY COLLEGE
Address
Royal College Street
NW1 OTU London
United Kingdom
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 559 448
Administrative Contact
Katharina Stärk (Prof.)

Participants (11)

STICHTING KATHOLIEKE UNIVERSITEIT
Netherlands
EU contribution
€ 297 408
Address
Geert Grooteplein Noord 9
6525 EZ Nijmegen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Hendrik-Jan Vos (Mr.)
KOBENHAVNS UNIVERSITET
Denmark
EU contribution
€ 497 585
Address
Norregade 10
1165 Kobenhavn
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Ivan Kristoffersen (Mr.)
UNIVERSITE LIBRE DE BRUXELLES
Belgium
EU contribution
€ 402 814
Address
Avenue Franklin Roosevelt 50
1050 Bruxelles
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Philippe Vincke (Prof.)
ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
Netherlands
EU contribution
€ 137 204
Address
Dr Molewaterplein 40
3015 GD Rotterdam
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Henri A. Verbrugh (Prof.)
ST GEORGE'S HOSPITAL MEDICAL SCHOOL
United Kingdom
EU contribution
€ 451 000
Address
Cranmer Terrace
SW17 0RE London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Carolyn Doughty (Ms.)
RIJKSINSTITUUT VOOR VOLKSGEZONDHEID EN MILIEU
Netherlands
EU contribution
€ 85 896
Address
Antonie Van Leeuwenhoeklaan 9
3721 MA Bilthoven
Activity type
Research Organisations
Administrative Contact
Marjon Straver-Hartwigsen
STATENS SERUM INSTITUT
Denmark
EU contribution
€ 194 359
Address
Artillerivej 5
2300 Kobenhavn S
Activity type
Research Organisations
Administrative Contact
Robert Skov (Dr.)
VYSOKA SKOLA CHEMICKO-TECHNOLOGICKA V PRAZE
Czechia
EU contribution
€ 67 800
Address
Technicka 5
166 28 Praha
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Anna Mittnerova (Dr.)
CENTRUM VOOR ONDERZOEK IN DIERGENEESKUNDE EN AGROCHEMIE - CODA
Belgium
EU contribution
€ 82 780
Address
Groeselenberg 99
1180 Bruxelles
Activity type
Research Organisations
Administrative Contact
Eefje Tuerlinckx
AGUACURE LIMITED
United Kingdom
EU contribution
€ 73 950
Address
Alun Roberts Building 9The Floor
LL57 2UW Bangor
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
John Bostock
ACCELOPMENT SCHWEIZ AG
Switzerland
EU contribution
€ 143 580
Address
Seefeldstrasse 198
8008 Zurich
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Jeanette Müller (Dr.)