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Combating Antibiotics Resistant Pneumococci by Novel Strategies Based on in vivo and in vitro Host – Pathogen Interactions

Objective

The diseases caused by Streptococcus pneumoniae are a major public health problem all over the world. Children, elderly people and immuno-compromised individuals are the high-risk targets for pneumococcal diseases. In spite of the availability of a large number of antibiotics the mortality and morbidity due to S. pneumoniae infections remain very high. There are two reasons for this: Firstly, the increasing antibiotic resistance among pneumococcal strains, and secondly, a current vaccine, though effective for certain serotypes, leads to serotype replacement. For the development of combat strategies it is essential to identify new intervention strategies, for which an understanding of host-pathogen interaction is a prerequisite. This proposal would apply a multi-disciplinary approach that includes epidemiology, host-pathogen interactions, infection models and intervention strategies to combat antibiotic resistant S. pneumoniae. The consortium brings together 12 research organizations and 1 SME with expertise in the above-mentioned areas. The major objectives of this consortium will be 1. monitoring of prevalent S. pneumoniae serotypes and their resistance profiles in different countries, 2. analysis of host-pathogen interactions and identification of potential therapeutic targets and vaccine candidates, 3. providing a basis for the development of improved vaccine and intervention strategies. This joint international effort would contribute towards novel control strategies, especially of antibiotic resistant S. pneumoniae strains.

Call for proposal

FP7-HEALTH-2007-B
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

HELMHOLTZ-ZENTRUM FUR INFEKTIONSFORSCHUNG GMBH
Address
Inhoffenstrasse 7
38124 Braunschweig
Germany
Activity type
Research Organisations
EU contribution
€ 648 992
Administrative Contact
Michael Strätz (Dr.)

Participants (12)

UNIVERSITAETSKLINIKUM AACHEN
Germany
EU contribution
€ 199 980
Address
Pauwelsstrasse 30
52074 Aachen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Volker Legewie (Mr.)
ETHNIKO KAI KAPODISTRIAKO PANEPISTIMIO ATHINON
Greece
EU contribution
€ 155 100
Address
6 Christou Lada Str
10561 Athina
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Efi Kafentzi (Ms.)
National Medicines Institute (Narodowy Instytut Lekow)
Poland
EU contribution
€ 138 600
Address
Chelmska
00-725 Warsaw
Activity type
Research Organisations
Administrative Contact
Renata Cellmer (Ms.)
INSTITUTO DE MEDICINA MOLECULAR JOAO LOBO ANTUNES
Portugal
EU contribution
€ 155 100
Address
Avenida Prof Egas Moniz
1649 028 Lisboa
Activity type
Research Organisations
Administrative Contact
Margarida Pinto Gago (Ms.)
HOSPITAL DE PEDIATRIA SAMIC PROF. DR. JUAN P. GARRAHAN
Argentina
EU contribution
€ 129 420
Address
Combate De Los Pozos 1881
1245 Buenos Aires
Activity type
Research Organisations
Administrative Contact
Josefa Rodrigues (Dr.)
POST GRADUATE INSTITUTE OF MEDICAL EDUCATION AND RESEARCH
India
EU contribution
€ 72 300
Address
Sector 12, Post Graduate Institute Of Medical Education And Research
160012 Chandigarh
Activity type
Research Organisations
Administrative Contact
Anuradha Chakraborti (Prof.)
UNIVERSITY OF GLASGOW
United Kingdom
EU contribution
€ 277 992
Address
University Avenue
G12 8QQ Glasgow
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Joe Galloway (Mr.)
AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
Spain
EU contribution
€ 344 115
Address
Calle Serrano 117
28006 Madrid
Activity type
Research Organisations
Administrative Contact
Carlos Manuel Abad Ruiz (Mr.)
UNIVERSIDAD MIGUEL HERNANDEZ DE ELCHE
Spain
EU contribution
€ 222 000
Address
Avenida De La Universidad S-n
03202 Elche
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Rafael Gandía-Balaguer (Mr.)
UNIVERSITATSSPITAL BASEL
Switzerland
EU contribution
€ 247 200
Address
Hebelstrasse 32
4031 Basel
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
Regine Landmann (Prof.)
Protea Vaccine Technologies Ltd.
Israel
EU contribution
€ 152 400
Address
South Industrial Area
11013 Kiryat Shmone
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Michael Tal (Dr.)
UNIVERSITAET GREIFSWALD
Germany
EU contribution
€ 256 800
Address
Domstrasse 11
17489 Greifswald
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Eckart Dietrich (Dr.)