Skip to main content

Mechanisms to Attack Steering Effectors of Rheumatoid Syndromes with Innovated Therapy Choices

Objective

Objective: To delineate the biological and molecular pathways that initiate and drive chronic inflammatory disease and to transform the knowledge obtained into the development of novel anti-inflammatory interventions. Focus will be given to Rheumatoid Arthritis (RA) since longitudinal data indicate that intensive treatment can prevent persistency and chronicity. State of the Art and beyond: The first generation of targeted therapies in chronic inflammatory disease used RA as prototype disease for clinical development. These therapies are now also used in other inflammatory disorders. Although treatments have been developed that are effective in a proportion of patients, they are aspecific, relatively toxic and do not mediate cure. Currently, it is unknown which molecular effects need to be induced and/or targeted to prevent induction or persistency of RA. However, this is within reach through a strong international consortium of world-leading European groups that cover both basic- and translational research. Work plan: The general strategy for the project is to enable parallel studies that are focussed on critical switch moments in the biological processes that drive chronicity of inflammation. As the consortium consists of a multidisciplinary team with basic- and clinical expertise, translational research will be conducted to delineate the molecular basis of dysregulated inflammation, the RA-specific autoimmune-response and organ specific pathobiology. The final aim is to develop novel- and specific anti-inflammatory therapies. Impact of the project: This project will (i) identify the molecular networks underlying chronic inflammation and thereby (ii) will define novel targets for drug-development as well as (iii) algorithms that will predict outcome of therapy. Moreover, within this project European SMEs will evaluate new interventions (iv) and this project will (v) offer a platform to rapidly develop ideas and patents into new therapies.

Call for proposal

FP7-HEALTH-2007-B
See other projects for this call

Funding Scheme

CP-IP - Large-scale integrating project

Coordinator

ACADEMISCH ZIEKENHUIS LEIDEN
Address
Albinusdreef 2
2333 ZA Leiden
Netherlands
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 2 312 611,96
Administrative Contact
Joyce Kuijper (Ms.)

Participants (19)

BIOMEDICAL SCIENCES RESEARCH CENTER ALEXANDER FLEMING
Greece
EU contribution
€ 944 480
Address
Fleming Street 34
16672 Vari-athens
Activity type
Research Organisations
Administrative Contact
George Kollias (Dr.)
IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
United Kingdom
EU contribution
€ 170 010
Address
South Kensington Campus Exhibition Road
SW7 2AZ London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Julie Williams (Ms.)
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France
EU contribution
€ 695 000
Address
Rue Michel Ange 3
75794 Paris
Activity type
Research Organisations
Administrative Contact
Béatrice Saint-Cricq (Ms.)
FRIEDRICH-ALEXANDER-UNIVERSITAET ERLANGEN-NUERNBERG
Germany
EU contribution
€ 501 444
Address
Schlossplatz 4
91054 Erlangen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Ulrike Herrmann (Ms.)
MEDIZINISCHE UNIVERSITAET WIEN
Austria
EU contribution
€ 806 200
Address
Spitalgasse 23
1090 Wien
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Josef Smolen (Prof.)
UNIVERSITY OF LEEDS
United Kingdom
EU contribution
€ 607 705,20
Address
Woodhouse Lane
LS2 9JT Leeds
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Kathy Brownridge (Ms.)
KAROLINSKA INSTITUTET
Sweden
EU contribution
€ 1 178 912
Address
Nobels Vag 5
17177 Stockholm
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Jill Blomstrand (Ms.)
UNIVERSITAT ZURICH
Switzerland
EU contribution
€ 675 000
Address
Ramistrasse 71
8006 Zürich
Activity type
Other
Administrative Contact
Steffen Gay (Prof.)
UNIVERSITAET ZU KOELN
Germany
EU contribution
€ 500 000
Address
Albertus Magnus Platz
50931 Koeln
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Petra Schreiner-Kaub (Ms.)
UNIVERSITY OF GLASGOW
United Kingdom
EU contribution
€ 423 828
Address
University Avenue
G12 8QQ Glasgow
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Derek Motherwell (Mr.)
AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS
Spain
EU contribution
€ 415 512
Address
Calle Serrano 117
28006 Madrid
Activity type
Research Organisations
Administrative Contact
Ma Del Mar Garcia (Ms.)
BIOMEDCODE ELLAS ANONIMI ETERIA EPISTIMONIKIS KAI TEXNOLOGIKIS EREVNAS KAI EMBORIKIS EKMETALLEFSIS EPHARMOGON IATRIKIS
Greece
EU contribution
€ 412 500
Address
Alexander Fleming Street 34
16672 Vari
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Nassos Alevizopoulos (Dr.)
Hybrigenics
France
EU contribution
€ 411 527
Address
Impasse Reille 3-5
75014 Paris
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Eric Cohen (Mr.)
MaimoniDex (UK) Ltd
United Kingdom
EU contribution
€ 412 500
Address
One London Wall, 6Th Floor
EC2Y 5EB London
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Itshak Golan (Dr.)
CRANFIELD UNIVERSITY
United Kingdom
EU contribution
€ 210 000,80
Address
College Road
MK43 0AL Cranfield - Bedfordshire
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Martin Ellis (Mr.)
KING'S COLLEGE LONDON
United Kingdom
EU contribution
€ 121 874,64
Address
Strand
WC2R 2LS London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Paul Labbett (Mr.)
THE UNIVERSITY OF SUSSEX
United Kingdom
EU contribution
€ 61 874,40
Address
Sussex House Falmer
BN1 9RH Brighton
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Julian Golland (Mr.)
REDOXIS AB
Sweden
EU contribution
€ 150 000
Address
Medicon Village Scheelevagen 2
223 81 Lund
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Peter Olofsson (Dr.)
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom
EU contribution
€ 225 000
Address
Wellington Square University Offices
OX1 2JD Oxford
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Linda Pialek (Ms.)