Objective Objective: To delineate the biological and molecular pathways that initiate and drive chronic inflammatory disease and to transform the knowledge obtained into the development of novel anti-inflammatory interventions. Focus will be given to Rheumatoid Arthritis (RA) since longitudinal data indicate that intensive treatment can prevent persistency and chronicity. State of the Art and beyond: The first generation of targeted therapies in chronic inflammatory disease used RA as prototype disease for clinical development. These therapies are now also used in other inflammatory disorders. Although treatments have been developed that are effective in a proportion of patients, they are aspecific, relatively toxic and do not mediate cure. Currently, it is unknown which molecular effects need to be induced and/or targeted to prevent induction or persistency of RA. However, this is within reach through a strong international consortium of world-leading European groups that cover both basic- and translational research. Work plan: The general strategy for the project is to enable parallel studies that are focussed on critical switch moments in the biological processes that drive chronicity of inflammation. As the consortium consists of a multidisciplinary team with basic- and clinical expertise, translational research will be conducted to delineate the molecular basis of dysregulated inflammation, the RA-specific autoimmune-response and organ specific pathobiology. The final aim is to develop novel- and specific anti-inflammatory therapies. Impact of the project: This project will (i) identify the molecular networks underlying chronic inflammation and thereby (ii) will define novel targets for drug-development as well as (iii) algorithms that will predict outcome of therapy. Moreover, within this project European SMEs will evaluate new interventions (iv) and this project will (v) offer a platform to rapidly develop ideas and patents into new therapies. Fields of science medical and health sciencesclinical medicinerheumatologymedical and health scienceshealth sciencesinflammatory diseases Keywords Rheumatoid Arthritis chronic inflammation inflammatory disease molecular pathways Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Topic(s) HEALTH-2007-2.4.5-12 - Early processes in the pathogenesis of chronic inflammatory diseases Call for proposal FP7-HEALTH-2007-B See other projects for this call Funding Scheme CP-IP - Large-scale integrating project Coordinator ACADEMISCH ZIEKENHUIS LEIDEN Address Albinusdreef 2 2333 ZA Leiden Netherlands See on map Region West-Nederland Zuid-Holland Agglomeratie Leiden en Bollenstreek Activity type Higher or Secondary Education Establishments Administrative Contact Joyce Kuijper (Ms.) Links Contact the organisation Opens in new window Website Opens in new window EU contribution € 2 312 611,96 Participants (19) Sort alphabetically Sort by EU Contribution Expand all Collapse all BIOMEDICAL SCIENCES RESEARCH CENTER ALEXANDER FLEMING Greece EU contribution € 944 480,00 Address Fleming street 34 16672 Vari-athens See on map Region Αττική Aττική Ανατολική Αττική Activity type Research Organisations Administrative Contact George Kollias (Dr.) Links Contact the organisation Opens in new window Website Opens in new window IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE United Kingdom EU contribution € 170 010,00 Address South kensington campus exhibition road SW7 2AZ London See on map Region London Inner London — West Westminster Activity type Higher or Secondary Education Establishments Administrative Contact Julie Williams (Ms.) Links Contact the organisation Opens in new window Website Opens in new window CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS France EU contribution € 695 000,00 Address Rue michel ange 3 75794 Paris See on map Region Ile-de-France Ile-de-France Paris Administrative Contact Béatrice Saint-Cricq (Ms.) Links Contact the organisation Opens in new window Website Opens in new window FRIEDRICH-ALEXANDER-UNIVERSITAET ERLANGEN-NUERNBERG Germany EU contribution € 501 444,00 Address Schlossplatz 4 91054 Erlangen See on map Region Bayern Mittelfranken Erlangen, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Administrative Contact Ulrike Herrmann (Ms.) Links Contact the organisation Opens in new window Website Opens in new window MEDIZINISCHE UNIVERSITAET WIEN Austria EU contribution € 806 200,00 Address Spitalgasse 23 1090 Wien See on map Region Ostösterreich Wien Wien Activity type Higher or Secondary Education Establishments Administrative Contact Josef Smolen (Prof.) Links Contact the organisation Opens in new window Website Opens in new window UNIVERSITY OF LEEDS United Kingdom EU contribution € 607 705,20 Address Woodhouse lane LS2 9JT Leeds See on map Region Yorkshire and the Humber West Yorkshire Leeds Activity type Higher or Secondary Education Establishments Administrative Contact Kathy Brownridge (Ms.) Links Contact the organisation Opens in new window Website Opens in new window KAROLINSKA INSTITUTET Sweden EU contribution € 1 178 912,00 Address Nobels vag 5 17177 Stockholm See on map Region Östra Sverige Stockholm Stockholms län Activity type Higher or Secondary Education Establishments Administrative Contact Jill Blomstrand (Ms.) Links Contact the organisation Opens in new window Website Opens in new window University of Zurich Switzerland EU contribution € 675 000,00 Address Ramistrasse 71 8006 Zurich See on map Activity type Higher or Secondary Education Establishments Administrative Contact Steffen Gay (Prof.) Links Contact the organisation Opens in new window Website Opens in new window UNIVERSITAT ZU KOLN Germany EU contribution € 500 000,00 Address Albertus magnus platz 50931 Koln See on map Region Nordrhein-Westfalen Köln Köln, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Administrative Contact Petra Schreiner-Kaub (Ms.) Links Contact the organisation Opens in new window Website Opens in new window UNIVERSITY OF GLASGOW United Kingdom EU contribution € 423 828,00 Address University avenue G12 8QQ Glasgow See on map Region Scotland West Central Scotland Glasgow City Activity type Higher or Secondary Education Establishments Administrative Contact Derek Motherwell (Mr.) Links Contact the organisation Opens in new window Website Opens in new window AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS Spain EU contribution € 415 512,00 Address Calle serrano 117 28006 Madrid See on map Region Comunidad de Madrid Comunidad de Madrid Madrid Administrative Contact Ma Del Mar Garcia (Ms.) Links Contact the organisation Opens in new window Website Opens in new window BIOMEDCODE ELLAS ANONIMI ETERIA EPISTIMONIKIS KAI TEXNOLOGIKIS EREVNAS KAI EMBORIKIS EKMETALLEFSIS EPHARMOGON IATRIKIS Greece EU contribution € 412 500,00 Address Alexander fleming street 34 16672 Vari See on map Region Αττική Aττική Ανατολική Αττική Administrative Contact Nassos Alevizopoulos (Dr.) Links Contact the organisation Opens in new window Website Opens in new window HYBRIGENICS SA France EU contribution € 411 527,00 Address Impasse reille 3-5 75014 Paris See on map Region Ile-de-France Ile-de-France Paris Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Eric Cohen (Mr.) Links Contact the organisation Opens in new window Website Opens in new window MaimoniDex (UK) Ltd United Kingdom EU contribution € 412 500,00 Address One london wall, 6th floor EC2Y 5EB London See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Itshak Golan (Dr.) Links Contact the organisation Opens in new window CRANFIELD UNIVERSITY United Kingdom EU contribution € 210 000,80 Address College road MK43 0AL Cranfield - bedfordshire See on map Region East of England Bedfordshire and Hertfordshire Central Bedfordshire Activity type Higher or Secondary Education Establishments Administrative Contact Martin Ellis (Mr.) Links Contact the organisation Opens in new window Website Opens in new window KING'S COLLEGE LONDON United Kingdom EU contribution € 121 874,64 Address Strand WC2R 2LS London See on map Region London Inner London — West Westminster Activity type Higher or Secondary Education Establishments Administrative Contact Paul Labbett (Mr.) Links Contact the organisation Opens in new window Website Opens in new window THE UNIVERSITY OF SUSSEX United Kingdom EU contribution € 61 874,40 Address Sussex house falmer BN1 9RH Brighton See on map Region South East (England) Surrey, East and West Sussex Brighton and Hove Activity type Higher or Secondary Education Establishments Administrative Contact Julian Golland (Mr.) Links Contact the organisation Opens in new window Website Opens in new window REDOXIS AB Sweden EU contribution € 150 000,00 Address Medicon village scheelevagen 2 223 81 Lund See on map Region Södra Sverige Sydsverige Skåne län Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Peter Olofsson (Dr.) Links Contact the organisation Opens in new window Website Opens in new window THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD United Kingdom EU contribution € 225 000,00 Address Wellington square university offices OX1 2JD Oxford See on map Region South East (England) Berkshire, Buckinghamshire and Oxfordshire Oxfordshire Activity type Higher or Secondary Education Establishments Administrative Contact Linda Pialek (Ms.) Links Contact the organisation Opens in new window Website Opens in new window
