Mechanisms to Attack Steering Effectors of Rheumatoid Syndromes with Innovated Therapy Choices

Informazioni relative al progetto

MASTERSWITCH

ID dell’accordo di sovvenzione: 223404

Progetto chiuso

Data di avvio 1 Dicembre 2008

Data di completamento 30 Novembre 2013

Finanziato da

• Specific Programme "Cooperation": Health

Costo totale € 14 805 808,18

Contributo UE € 11 235 980,00

Coordinato da

ACADEMISCH ZIEKENHUIS LEIDEN
Netherlands

Obiettivo

Objective: To delineate the biological and molecular pathways that initiate and drive chronic inflammatory disease and to transform the knowledge obtained into the development of novel anti-inflammatory interventions. Focus will be given to Rheumatoid Arthritis (RA) since longitudinal data indicate that intensive treatment can prevent persistency and chronicity. State of the Art and beyond: The first generation of targeted therapies in chronic inflammatory disease used RA as prototype disease for clinical development. These therapies are now also used in other inflammatory disorders. Although treatments have been developed that are effective in a proportion of patients, they are aspecific, relatively toxic and do not mediate cure. Currently, it is unknown which molecular effects need to be induced and/or targeted to prevent induction or persistency of RA. However, this is within reach through a strong international consortium of world-leading European groups that cover both basic- and translational research. Work plan: The general strategy for the project is to enable parallel studies that are focussed on critical switch moments in the biological processes that drive chronicity of inflammation. As the consortium consists of a multidisciplinary team with basic- and clinical expertise, translational research will be conducted to delineate the molecular basis of dysregulated inflammation, the RA-specific autoimmune-response and organ specific pathobiology. The final aim is to develop novel- and specific anti-inflammatory therapies. Impact of the project: This project will (i) identify the molecular networks underlying chronic inflammation and thereby (ii) will define novel targets for drug-development as well as (iii) algorithms that will predict outcome of therapy. Moreover, within this project European SMEs will evaluate new interventions (iv) and this project will (v) offer a platform to rapidly develop ideas and patents into new therapies.

Campo scientifico

• medical and health sciences › clinical medicine › rheumatology
• medical and health sciences › health sciences › inflammatory diseases

Parole chiave

• Rheumatoid Arthritis
• chronic inflammation
• inflammatory disease
• molecular pathways

Programma(i)

• FP7-HEALTH - Specific Programme "Cooperation": Health

Argomento(i)

• HEALTH-2007-2.4.5-12 - Early processes in the pathogenesis of chronic inflammatory diseases

Invito a presentare proposte

FP7-HEALTH-2007-B
Vedi altri progetti per questo bando

Meccanismo di finanziamento

CP-IP - Large-scale integrating project

Coordinatore

ACADEMISCH ZIEKENHUIS LEIDEN

• Contributo UE: € 2 312 611,96
• Indirizzo: ALBINUSDREEF 2 ; 2333 ZA Leiden ; Paesi Bassi
• Regione: West-Nederland › Zuid-Holland › Agglomeratie Leiden en Bollenstreek
• Tipo di attività: Higher or Secondary Education Establishments
• Contatto amministrativo: Joyce Kuijper (Ms.)
• Costo totale: Nessun dato

Partecipanti (19)

EREVNITIKO KENTRO VIOIATRIKON EPISTIMON ALEXANDROS FLEMINGK

Grecia

• Contributo UE: € 944 480,00
• Indirizzo: FLEMING STREET 34 ; 16672 Vari-Athens
• Regione: Αττική › Aττική › Ανατολική Αττική
• Tipo di attività: Research Organisations
• Contatto amministrativo: George Kollias (Dr.)
• Costo totale: Nessun dato

IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE

Regno Unito

• Contributo UE: € 170 010,00
• Indirizzo: SOUTH KENSINGTON CAMPUS EXHIBITION ROAD ; SW7 2AZ LONDON
• Regione: London › Inner London — West › Westminster
• Tipo di attività: Higher or Secondary Education Establishments
• Contatto amministrativo: Julie Williams (Ms.)
• Costo totale: Nessun dato

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS

Francia

• Contributo UE: € 695 000,00
• Indirizzo: RUE MICHEL ANGE 3 ; 75794 Paris
• Regione: Ile-de-France › Ile-de-France › Paris
• Tipo di attività: Research Organisations
• Contatto amministrativo: Béatrice Saint-Cricq (Ms.)
• Costo totale: Nessun dato

FRIEDRICH-ALEXANDER-UNIVERSITAET ERLANGEN-NUERNBERG

Germania

• Contributo UE: € 501 444,00
• Indirizzo: SCHLOSSPLATZ 4 ; 91054 Erlangen
• Regione: Bayern › Mittelfranken › Erlangen, Kreisfreie Stadt
• Tipo di attività: Higher or Secondary Education Establishments
• Contatto amministrativo: Ulrike Herrmann (Ms.)
• Costo totale: Nessun dato

MEDIZINISCHE UNIVERSITAET WIEN

Austria

• Contributo UE: € 806 200,00
• Indirizzo: SPITALGASSE 23 ; 1090 Wien
• Regione: Ostösterreich › Wien › Wien
• Tipo di attività: Higher or Secondary Education Establishments
• Contatto amministrativo: Josef Smolen (Prof.)
• Costo totale: Nessun dato

UNIVERSITY OF LEEDS

Regno Unito

• Contributo UE: € 607 705,20
• Indirizzo: WOODHOUSE LANE ; LS2 9JT Leeds
• Regione: Yorkshire and the Humber › West Yorkshire › Leeds
• Tipo di attività: Higher or Secondary Education Establishments
• Contatto amministrativo: Kathy Brownridge (Ms.)
• Costo totale: Nessun dato

KAROLINSKA INSTITUTET

Svezia

• Contributo UE: € 1 178 912,00
• Indirizzo: Nobels Vag 5 ; 17177 Stockholm
• Regione: Östra Sverige › Stockholm › Stockholms län
• Tipo di attività: Higher or Secondary Education Establishments
• Contatto amministrativo: Jill Blomstrand (Ms.)
• Costo totale: Nessun dato

University of Zurich

Svizzera

• Contributo UE: € 675 000,00
• Indirizzo: RAMISTRASSE 71 ; 8006 ZURICH
• Tipo di attività: Higher or Secondary Education Establishments
• Contatto amministrativo: Steffen Gay (Prof.)
• Costo totale: Nessun dato

UNIVERSITAT ZU KOLN

Germania

• Contributo UE: € 500 000,00
• Indirizzo: ALBERTUS MAGNUS PLATZ ; 50931 Koln
• Regione: Nordrhein-Westfalen › Köln › Köln, Kreisfreie Stadt
• Tipo di attività: Higher or Secondary Education Establishments
• Contatto amministrativo: Petra Schreiner-Kaub (Ms.)
• Costo totale: Nessun dato

UNIVERSITY OF GLASGOW

Regno Unito

• Contributo UE: € 423 828,00
• Indirizzo: UNIVERSITY AVENUE ; G12 8QQ Glasgow
• Regione: Scotland › West Central Scotland › Glasgow City
• Tipo di attività: Higher or Secondary Education Establishments
• Contatto amministrativo: Derek Motherwell (Mr.)
• Costo totale: Nessun dato

AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS

Spagna

• Contributo UE: € 415 512,00
• Indirizzo: CALLE SERRANO 117 ; 28006 Madrid
• Regione: Comunidad de Madrid › Comunidad de Madrid › Madrid
• Tipo di attività: Research Organisations
• Contatto amministrativo: Ma Del Mar Garcia (Ms.)
• Costo totale: Nessun dato

BIOMEDCODE ELLAS ANONIMI ETERIA EPISTIMONIKIS KAI TEXNOLOGIKIS EREVNAS KAI EMBORIKIS EKMETALLEFSIS EPHARMOGON IATRIKIS

Grecia

• Contributo UE: € 412 500,00
• Indirizzo: ALEXANDER FLEMING STREET 34 ; 16672 Vari
• Regione: Αττική › Aττική › Ανατολική Αττική
• Tipo di attività: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Contatto amministrativo: Nassos Alevizopoulos (Dr.)
• Costo totale: Nessun dato

HYBRIGENICS SA

Francia

• Contributo UE: € 411 527,00
• Indirizzo: IMPASSE REILLE 3-5 ; 75014 Paris
• Regione: Ile-de-France › Ile-de-France › Paris
• Tipo di attività: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Contatto amministrativo: Eric Cohen (Mr.)
• Costo totale: Nessun dato

MaimoniDex (UK) Ltd

Regno Unito

• Contributo UE: € 412 500,00
• Indirizzo: ONE LONDON WALL, 6TH FLOOR ; EC2Y 5EB LONDON
• Tipo di attività: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Contatto amministrativo: Itshak Golan (Dr.)
• Costo totale: Nessun dato

CRANFIELD UNIVERSITY

Regno Unito

• Contributo UE: € 210 000,80
• Indirizzo: College Road ; MK43 0AL Cranfield - Bedfordshire
• Regione: East of England › Bedfordshire and Hertfordshire › Central Bedfordshire
• Tipo di attività: Higher or Secondary Education Establishments
• Contatto amministrativo: Martin Ellis (Mr.)
• Costo totale: Nessun dato

KING'S COLLEGE LONDON

Regno Unito

• Contributo UE: € 121 874,64
• Indirizzo: STRAND ; WC2R 2LS London
• Regione: London › Inner London — West › Westminster
• Tipo di attività: Higher or Secondary Education Establishments
• Contatto amministrativo: Paul Labbett (Mr.)
• Costo totale: Nessun dato

THE UNIVERSITY OF SUSSEX

Regno Unito

• Contributo UE: € 61 874,40
• Indirizzo: SUSSEX HOUSE FALMER ; BN1 9RH Brighton
• Regione: South East (England) › Surrey, East and West Sussex › Brighton and Hove
• Tipo di attività: Higher or Secondary Education Establishments
• Contatto amministrativo: Julian Golland (Mr.)
• Costo totale: Nessun dato

REDOXIS AB

Svezia

• Contributo UE: € 150 000,00
• Indirizzo: MEDICON VILLAGE SCHEELEVAGEN 2 ; 223 81 Lund
• Regione: Södra Sverige › Sydsverige › Skåne län
• Tipo di attività: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Contatto amministrativo: Peter Olofsson (Dr.)
• Costo totale: Nessun dato

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD

Regno Unito

• Contributo UE: € 225 000,00
• Indirizzo: WELLINGTON SQUARE UNIVERSITY OFFICES ; OX1 2JD Oxford
• Regione: South East (England) › Berkshire, Buckinghamshire and Oxfordshire › Oxfordshire
• Tipo di attività: Higher or Secondary Education Establishments
• Contatto amministrativo: Linda Pialek (Ms.)
• Costo totale: Nessun dato