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Mechanisms to Attack Steering Effectors of Rheumatoid Syndromes with Innovated Therapy Choices

Obiettivo

Objective: To delineate the biological and molecular pathways that initiate and drive chronic inflammatory disease and to transform the knowledge obtained into the development of novel anti-inflammatory interventions. Focus will be given to Rheumatoid Arthritis (RA) since longitudinal data indicate that intensive treatment can prevent persistency and chronicity. State of the Art and beyond: The first generation of targeted therapies in chronic inflammatory disease used RA as prototype disease for clinical development. These therapies are now also used in other inflammatory disorders. Although treatments have been developed that are effective in a proportion of patients, they are aspecific, relatively toxic and do not mediate cure. Currently, it is unknown which molecular effects need to be induced and/or targeted to prevent induction or persistency of RA. However, this is within reach through a strong international consortium of world-leading European groups that cover both basic- and translational research. Work plan: The general strategy for the project is to enable parallel studies that are focussed on critical switch moments in the biological processes that drive chronicity of inflammation. As the consortium consists of a multidisciplinary team with basic- and clinical expertise, translational research will be conducted to delineate the molecular basis of dysregulated inflammation, the RA-specific autoimmune-response and organ specific pathobiology. The final aim is to develop novel- and specific anti-inflammatory therapies. Impact of the project: This project will (i) identify the molecular networks underlying chronic inflammation and thereby (ii) will define novel targets for drug-development as well as (iii) algorithms that will predict outcome of therapy. Moreover, within this project European SMEs will evaluate new interventions (iv) and this project will (v) offer a platform to rapidly develop ideas and patents into new therapies.

Invito a presentare proposte

FP7-HEALTH-2007-B
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Coordinatore

ACADEMISCH ZIEKENHUIS LEIDEN
Indirizzo
Albinusdreef 2
2333 ZA Leiden
Paesi Bassi

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Tipo di attività
Higher or Secondary Education Establishments
Contatto amministrativo
Joyce Kuijper (Ms.)
Contributo UE
€ 2 312 611,96

Partecipanti (19)

BIOMEDICAL SCIENCES RESEARCH CENTER ALEXANDER FLEMING
Grecia
Contributo UE
€ 944 480
Indirizzo
Fleming Street 34
16672 Vari-athens

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Tipo di attività
Research Organisations
Contatto amministrativo
George Kollias (Dr.)
IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
United Kingdom
Contributo UE
€ 170 010
Indirizzo
South Kensington Campus Exhibition Road
SW7 2AZ London

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Tipo di attività
Higher or Secondary Education Establishments
Contatto amministrativo
Julie Williams (Ms.)
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
Francia
Contributo UE
€ 695 000
Indirizzo
Rue Michel Ange 3
75794 Paris

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Tipo di attività
Research Organisations
Contatto amministrativo
Béatrice Saint-Cricq (Ms.)
FRIEDRICH-ALEXANDER-UNIVERSITAET ERLANGEN-NUERNBERG
Germania
Contributo UE
€ 501 444
Indirizzo
Schlossplatz 4
91054 Erlangen

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Tipo di attività
Higher or Secondary Education Establishments
Contatto amministrativo
Ulrike Herrmann (Ms.)
MEDIZINISCHE UNIVERSITAET WIEN
Austria
Contributo UE
€ 806 200
Indirizzo
Spitalgasse 23
1090 Wien

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Tipo di attività
Higher or Secondary Education Establishments
Contatto amministrativo
Josef Smolen (Prof.)
UNIVERSITY OF LEEDS
United Kingdom
Contributo UE
€ 607 705,20
Indirizzo
Woodhouse Lane
LS2 9JT Leeds

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Tipo di attività
Higher or Secondary Education Establishments
Contatto amministrativo
Kathy Brownridge (Ms.)
KAROLINSKA INSTITUTET
Svezia
Contributo UE
€ 1 178 912
Indirizzo
Nobels Vag 5
17177 Stockholm

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Tipo di attività
Higher or Secondary Education Establishments
Contatto amministrativo
Jill Blomstrand (Ms.)
University of Zurich
Svizzera
Contributo UE
€ 675 000
Indirizzo
Ramistrasse 71
8006 Zurich

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Tipo di attività
Higher or Secondary Education Establishments
Contatto amministrativo
Steffen Gay (Prof.)
UNIVERSITAT ZU KOLN
Germania
Contributo UE
€ 500 000
Indirizzo
Albertus Magnus Platz
50931 Koln

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Tipo di attività
Higher or Secondary Education Establishments
Contatto amministrativo
Petra Schreiner-Kaub (Ms.)
UNIVERSITY OF GLASGOW
United Kingdom
Contributo UE
€ 423 828
Indirizzo
University Avenue
G12 8QQ Glasgow

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Tipo di attività
Higher or Secondary Education Establishments
Contatto amministrativo
Derek Motherwell (Mr.)
AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
Spagna
Contributo UE
€ 415 512
Indirizzo
Calle Serrano 117
28006 Madrid

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Tipo di attività
Research Organisations
Contatto amministrativo
Ma Del Mar Garcia (Ms.)
BIOMEDCODE ELLAS ANONIMI ETERIA EPISTIMONIKIS KAI TEXNOLOGIKIS EREVNAS KAI EMBORIKIS EKMETALLEFSIS EPHARMOGON IATRIKIS
Grecia
Contributo UE
€ 412 500
Indirizzo
Alexander Fleming Street 34
16672 Vari

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Tipo di attività
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contatto amministrativo
Nassos Alevizopoulos (Dr.)
HYBRIGENICS SA
Francia
Contributo UE
€ 411 527
Indirizzo
Impasse Reille 3-5
75014 Paris

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Tipo di attività
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contatto amministrativo
Eric Cohen (Mr.)
MaimoniDex (UK) Ltd
United Kingdom
Contributo UE
€ 412 500
Indirizzo
One London Wall, 6th Floor
EC2Y 5EB London

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Tipo di attività
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contatto amministrativo
Itshak Golan (Dr.)
CRANFIELD UNIVERSITY
United Kingdom
Contributo UE
€ 210 000,80
Indirizzo
College Road
MK43 0AL Cranfield - Bedfordshire

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Tipo di attività
Higher or Secondary Education Establishments
Contatto amministrativo
Martin Ellis (Mr.)
KING'S COLLEGE LONDON
United Kingdom
Contributo UE
€ 121 874,64
Indirizzo
Strand
WC2R 2LS London

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Tipo di attività
Higher or Secondary Education Establishments
Contatto amministrativo
Paul Labbett (Mr.)
THE UNIVERSITY OF SUSSEX
United Kingdom
Contributo UE
€ 61 874,40
Indirizzo
Sussex House Falmer
BN1 9RH Brighton

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Tipo di attività
Higher or Secondary Education Establishments
Contatto amministrativo
Julian Golland (Mr.)
REDOXIS AB
Svezia
Contributo UE
€ 150 000
Indirizzo
Medicon Village Scheelevagen 2
223 81 Lund

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Tipo di attività
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contatto amministrativo
Peter Olofsson (Dr.)
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom
Contributo UE
€ 225 000
Indirizzo
Wellington Square University Offices
OX1 2JD Oxford

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Tipo di attività
Higher or Secondary Education Establishments
Contatto amministrativo
Linda Pialek (Ms.)