Objective The TRIREME project aims at developing and implementing a multidisciplinary strategy for a systems-level analysis of a cornerstone of cellular homeostasis – the DNA damage response (DDR). The DDR is a complex signaling network that is responsible for maintaining the stability and integrity of the cellular genome in the face of DNA damage. DDR defects underlie acute and chronic forms of human ailments that involve tissue degeneration, premature ageing, sensitivity to environmental agents and cancer predisposition. Importantly, many cancer treatment regimens are based on DNA damaging agents. Therefore, gaining systems-level understanding of the DDR is of paramount importance for human health. TRIREME brings together a multidisciplinary consortium of six world-leading researchers with long-standing expertise in the DDR, cell cycle control, functional genomics, proteomics and computational biology. It will focus on a prototypic DNA damage inducer – ionizing radiation (IR), used extensively in cancer radiotherapy. The critical IR-induced DNA lesion is the double strand break, which vigorously activates the DDR. We will systematically analyze the IR-induced network in all its major layers: gene expression, microRNA expression, the proteome, and key protein post-translational modifications. The analysis is aimed at obtaining a global view of the DDR, and identifying new players in the network. The data obtained by these different approaches will be integrated into coherent models using novel computational algorithms developed for TRIREME. To the best of our knowledge, such an analysis has not been applied before to mammalian systems. The results are expected to have far-reaching ramifications in various biomedical fields, with special importance for clinical oncology. Fields of science natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsproteomicsnatural sciencesbiological sciencesgeneticsDNAnatural sciencesphysical sciencesnuclear physicsmedical and health sciencesclinical medicineoncologynatural sciencesbiological sciencesgeneticsgenomes Keywords DNA damage responses functional genomics ionizing radiation microRNA proteomics signaling networks systems biology Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Topic(s) HEALTH-2007-2.1.2-5 - Multidisciplinary fundamental genomics and molecular biology approaches to study basic biological processes relevant to health and diseases Call for proposal FP7-HEALTH-2007-B See other projects for this call Funding Scheme CP-FP - Small or medium-scale focused research project Coordinator TEL AVIV UNIVERSITY EU contribution € 1 049 920,00 Address RAMAT AVIV 69978 Tel Aviv Israel See on map Activity type Higher or Secondary Education Establishments Administrative Contact Lea Pais (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Participants (4) Sort alphabetically Sort by EU Contribution Expand all Collapse all THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE United Kingdom EU contribution € 505 380,00 Address TRINITY LANE THE OLD SCHOOLS CB2 1TN Cambridge See on map Region East of England East Anglia Cambridgeshire CC Activity type Higher or Secondary Education Establishments Administrative Contact Edna Murphy (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data USTAV MOLEKULARNI GENETIKY AKADEMIE VED CESKE REPUBLIKY VEREJNA VYZKUMNA INSTITUCE Czechia EU contribution € 425 000,00 Address VIDENSKA 1083 142 20 Praha 4 See on map Region Česko Praha Hlavní město Praha Activity type Research Organisations Administrative Contact Jiri Bartek (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV Germany EU contribution € 508 876,00 Address HOFGARTENSTRASSE 8 80539 Munchen See on map Region Bayern Oberbayern München, Kreisfreie Stadt Activity type Research Organisations Administrative Contact Joachim Gerlach (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH Switzerland EU contribution € 439 250,00 Address Raemistrasse 101 8092 Zuerich See on map Region Schweiz/Suisse/Svizzera Zürich Zürich Activity type Higher or Secondary Education Establishments Administrative Contact Ruedi Aebersold (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data
