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Understanding and combating human age-related muscle weakness

Objective

Ageing of skeletal muscle results in a progressive loss of mobility that decreases the quality of life and has major economic and social consequences for society at large. Increasing muscle weakness is a major component of muscle ageing. In the elderly muscles become atrophic (loss in muscle mass) and weaker (loss in muscle force), more susceptible to damage and consequently regenerate and recover more slowly than was the case in their youth. The challenge for FP7 is to identify the relative importance of sarcopaenia, thus proposing standards to define healthy ageing in order to identify age-related muscle weakness; secondly to identify molecular pathways which may be targeted to combat normal age related muscle weakness, and thirdly to identify therapeutic strategies to prevent muscle loss and weakness and enhance recovery following injury or immobilisation. The approaches which we will take to understand and combat muscle weakness in the aged population and improve healthspan can be defined in several steps: the collection and collation of data and samples, the assessment of physiological and functional parameters, the understanding of the various biological mechanisms involved, leading through integration to the development of strategies and their translation for the general European population. In order to develop and propose the general public with efficient countermeasures, the consortium will integrate data from genetics and epidemiology, molecular and cellular biology, physiology, biomechanics, as well as clinical and public health aspects, to ensure optimal scientific synergy from the leading European specialists and companies.

Field of science

  • /medical and health sciences/health sciences/public and environmental health
  • /natural sciences/biological sciences/genetics and heredity
  • /medical and health sciences/health sciences/epidemiology
  • /medical and health sciences/basic medicine/physiology

Call for proposal

FP7-HEALTH-2007-B
See other projects for this call

Funding Scheme

CP-IP - Large-scale integrating project

Coordinator

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
Address
Rue De Tolbiac 101
75654 Paris
France
Activity type
Research Organisations
EU contribution
€ 1 076 404
Administrative Contact
Mihaja Auguste (Ms.)

Participants (17)

FONDAZIONE PER LA RICERCA BIOMEDICA AVANZATA ONLUS
Italy
EU contribution
€ 589 916
Address
Via Orus Giuseppe 2
35129 Padova
Activity type
Research Organisations
Administrative Contact
Carla Tonin (Dr.)
UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA
Italy
EU contribution
€ 567 516
Address
Piazzale Aldo Moro 5
00185 Roma
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Daniela Merelli (Dr.)
REGION HOVEDSTADEN
Denmark
EU contribution
€ 1 079 708
Address
Kongens Vaenge 2
3400 Hillerod
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
Inge Holm (Ms.)
THE MANCHESTER METROPOLITAN UNIVERSITY
United Kingdom
EU contribution
€ 590 400
Address
Oxford Road All Saints Building
M15 6BH Manchester
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Maggy Taylor (Ms.)
ALMA MATER STUDIORUM - UNIVERSITA DI BOLOGNA
Italy
EU contribution
€ 565 764
Address
Via Zamboni 33
40126 Bologna
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Andrea Previti (Dr.)
UNIVERSITA DEGLI STUDI DI PAVIA
Italy
EU contribution
€ 288 400
Address
Strada Nuova 65
27100 Pavia
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Patrizia Bova (Dr.)
ACADEMISCH ZIEKENHUIS LEIDEN
Netherlands
EU contribution
€ 664 504
Address
Albinusdreef 2
2333 ZA Leiden
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Tineke Sanchez (Ms.)
UNIVERSITE DE NAMUR ASBL
Belgium
EU contribution
€ 556 116
Address
Rue De Bruxelles 61
5000 Namur
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Daniel Bourgeois (Mr.)
UNIVERSIDAD POMPEU FABRA
Spain
EU contribution
€ 575 839
Address
Placa De La Merce, 10-12
08002 Barcelona
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Eva Martin (Ms.)
UNIVERSITA DEGLI STUDI DI PADOVA
Italy
EU contribution
€ 834 050
Address
Via 8 Febbraio 2
35122 Padova
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Paolo Bernardi (Prof.)
UNIVERSITE PIERRE ET MARIE CURIE - PARIS 6
France
EU contribution
€ 564 640
Address
Place Jussieu 4
75252 Paris
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Thomas Wiest (Mr.)
KAYSER ITALIA SRL
Italy
EU contribution
€ 523 871
Address
Via Di Popogna 501
57128 Livorno
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Valfredo Zolesi (Dr.)
UNILEVER U.K. CENTRAL RESOURCES LIMITED
United Kingdom
EU contribution
€ 252 766
Address
Unilever House, Victoria Embankment 100
EC4Y 0DY London
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Kavita Karnik (Dr.)
TARTU ULIKOOL
Estonia
EU contribution
€ 557 920
Address
Ulikooli 18
51005 Tartu
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Enn Seppet (Prof.)
JYVASKYLAN YLIOPISTO
Finland
EU contribution
€ 576 960
Address
Seminaarinkatu 15
40100 Jyvaskyla
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Harri Suominen (Prof.)
UPPSALA UNIVERSITET
Sweden
EU contribution
€ 545 116
Address
Von Kraemers Alle 4
751 05 Uppsala
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Inger Hedlund (Ms.)
INSERM TRANSFERT SA
France
EU contribution
€ 790 110
Address
Rue Watt 7
75013 Paris
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Louis Jammayrac (Mr.)