Objectif
Ageing of skeletal muscle results in a progressive loss of mobility that decreases the quality of life and has major economic and social consequences for society at large. Increasing muscle weakness is a major component of muscle ageing. In the elderly muscles become atrophic (loss in muscle mass) and weaker (loss in muscle force), more susceptible to damage and consequently regenerate and recover more slowly than was the case in their youth. The challenge for FP7 is to identify the relative importance of sarcopaenia, thus proposing standards to define healthy ageing in order to identify age-related muscle weakness; secondly to identify molecular pathways which may be targeted to combat normal age related muscle weakness, and thirdly to identify therapeutic strategies to prevent muscle loss and weakness and enhance recovery following injury or immobilisation. The approaches which we will take to understand and combat muscle weakness in the aged population and improve healthspan can be defined in several steps: the collection and collation of data and samples, the assessment of physiological and functional parameters, the understanding of the various biological mechanisms involved, leading through integration to the development of strategies and their translation for the general European population. In order to develop and propose the general public with efficient countermeasures, the consortium will integrate data from genetics and epidemiology, molecular and cellular biology, physiology, biomechanics, as well as clinical and public health aspects, to ensure optimal scientific synergy from the leading European specialists and companies.
Champ scientifique
Mots‑clés
Appel à propositions
FP7-HEALTH-2007-B
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Régime de financement
CP-IP - Large-scale integrating projectCoordinateur
75654 Paris
France
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Participants (17)
35129 Padova
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00185 Roma
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3400 Hillerod
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M15 6BH Manchester
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40126 Bologna
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27100 Pavia
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2333 ZA Leiden
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5000 Namur
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08002 Barcelona
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35122 Padova
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75252 PARIS
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57128 Livorno
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EC4Y 0DY LONDON
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51005 Tartu
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40100 Jyvaskyla
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751 05 Uppsala
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75015 PARIS
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