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Determining Optimal non-invasive Parameters for the Prediction of Left vEntricular morphologic and functional Remodeling in Chronic Ischemic Patients

Objective

Coronary artery disease (CAD) remains the primary cause of cardiovascular morbidity and mortality in Europe. In current clinical practice, patients with chronic CAD are followed using non-invasive imaging methodologies for possible adverse morphologic remodelling and functional recovery of the myocardium before the decision for invasive examinations and treatments is taken. Technological developments have brought about several newer imaging methodologies (and associated parameters) that have shown accurate prognostic results under study conditions in selected patient populations. Each of these methodologies offers intrinsic advantages and disadvantages due to the physiologic processes it tries to assess, due to the technology it requires or due to its availability (often determined by its associated cost). However, to date, no large scale studies have made a direct comparison of the different methodologies towards predicting adverse morphologic remodelling or functional recovery of the myocardium after medical therapy. The lack of such information results in a sub-optimal use of the methodologies at hand. The aim of DOPPLER-CIP is therefore to conduct a multi-centre clinical study including about 1200 patients in order to determine the optimal prognostic parameters derived from (new) non-invasive imaging for a patient presenting with suspected chronic ischemic heart disease. The modality used to extract these parameters is of secondary importance. However, as both the accuracy and the cost related to extracting a particular parameter is modality-dependent, DOPPLER-CIP will also make a cost-effectiveness analysis in order to determine which modality should preferentially be used to extract the clinically most relevant parameter.

Field of science

  • /social sciences/sociology/demography/mortality

Call for proposal

FP7-HEALTH-2007-B
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

KATHOLIEKE UNIVERSITEIT LEUVEN
Address
Oude Markt 13
3000 Leuven
Belgium
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 751 891,60
Administrative Contact
Elke Lammertyn (Ms.)

Participants (9)

VARSINAIS-SUOMEN SAIRAANHOITOPIIRIN KUNTAYHTYMA
Finland
EU contribution
€ 99 237,60
Address
Kiinamyllynkatu 4-8
20520 Turku
Activity type
Research Organisations
Administrative Contact
Anne Lindqvist (Ms.)
SERVICIO MADRILENO DE SALUD
Spain
EU contribution
€ 183 152,40
Address
Plaza Carlos Trias Bertran 7
28020 Madrid
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
Antonio Portolés Perez (Mr.)
CONSIGLIO NAZIONALE DELLE RICERCHE
Italy
EU contribution
€ 159 184
Address
Piazzale Aldo Moro 7
00185 Roma
Activity type
Research Organisations
Administrative Contact
Eugenio Picano (Mr.)
KING'S COLLEGE HOSPITAL NHS FOUNDATION TRUST
United Kingdom
EU contribution
€ 215 115
Address
Denmark Hill
SE5 9RS London
Activity type
Research Organisations
Administrative Contact
Kirsty Hedditch (Ms.)
LINKOPINGS UNIVERSITET
Sweden
EU contribution
€ 643 214,40
Address
Campus Valla
581 83 Linkoping
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Elisabeth Helltegen (Ms.)
ADVANCED MEDICAL IMAGING DEVELOPMENT SRL
Italy
EU contribution
€ 100 825,20
Address
Via Circonvallazione Occidentale 2
67039 Sulmona
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Giovanni Tonti (Dr.)
KING'S COLLEGE LONDON
United Kingdom
EU contribution
€ 112 832,40
Address
Strand
WC2R 2LS London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Paul Labbett (Mr.)
OSLO UNIVERSITETSSYKEHUS HF
Norway
EU contribution
€ 287 090,40
Address
Kirkeveien 166 Tarnbygget
0450 Oslo
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Geir Gogstad (Dr.)
UNIVERSITA DI PISA
Italy
EU contribution
€ 62 454
Address
Lungarno Pacinotti 43/44
56126 Pisa
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Andrea Degl'innocenti (Ms.)