Description du projet
Virtual Physiological Human
TThe VPHOP research project will develop, validate and deploy to pilot clinical studies the next generation of technology for predicting the risk of fracture in patients with low bone mass.
Nearly four million osteoporotic bone fractures cost the European health system more than 30 billion Euro per year. This figure could double by 2050. After the first fracture, the chances of having another one increase by 86%. We need to prevent osteoporotic fractures. The first step is an accurate prediction of the patient-specific risk of fracture that considers not only the skeletal determinants but also the neuromuscular condition. The aim of VPHOP is to develop a multiscale modelling technology based on conventional diagnostic imaging methods that makes it possible, in a clinical setting, to predict for each patient the strength of his/her bones, how this strength is likely to change over time, and the probability that the he/she will overload his/her bones during daily life. With these three predictions, the evaluation of the absolute risk of bone fracture will be much more accurate than any prediction based on external and indirect determinants, as it is current clinical practice. These predictions will be used to: i) improve the diagnostic accuracy of the current clinical standards; ii) to provide the basis for an evidence-based prognosis with respect to the natural evolution of the disease, to pharmacological treatments, and/or to preventive interventional treatments aimed to selectively strengthen particularly weak regions of the skeleton. For patients at high risk of fracture, and for which the pharmacological treatment appears insufficient, the VPHOP system will also assist the interventional radiologist in planning the augmentation procedure. The various modelling technologies developed during the project will be validated not only in vitro, on animal models, or against retrospective clinical outcomes, but will also be assessed in term of clinical impact and safety on small cohorts of patients enrolled at four different clinical institutions, providing the factual basis for effective clinical and industrial exploitations.
Champ scientifique
Appel à propositions
FP7-ICT-2007-2
Voir d’autres projets de cet appel
Régime de financement
CP - Collaborative project (generic)Coordinateur
40136 Bologna
Italie
Voir sur la carte
Participants (21)
3000 Leuven
Voir sur la carte
8092 Zuerich
Voir sur la carte
1211 Geneve
Voir sur la carte
3012 Bern
Voir sur la carte
301 00 Pilsen
Voir sur la carte
85622 FELDKIRCHEN
Voir sur la carte
53111 Bonn
Voir sur la carte
10117 Berlin
Voir sur la carte
81677 MUENCHEN
Voir sur la carte
75654 Paris
Voir sur la carte
75011 PARIS
Voir sur la carte
78180 Montigny Le Bretonneux
Voir sur la carte
75013 PARIS 13
Voir sur la carte
Participation terminée
69100 VILLEURBANNE
Voir sur la carte
101 Reykjavik
Voir sur la carte
40033 CASALECCHIO DI RENO
Voir sur la carte
5684 PC Best
Voir sur la carte
5612 AE Eindhoven
Voir sur la carte
751 05 Uppsala
Voir sur la carte
LU1 3JU Luton
Voir sur la carte
S10 2TN Sheffield
Voir sur la carte