Project description
Virtual Physiological Human
In 2006, over 45.000 European citizens died of cirrhosis of the liver and 44,000 additional citizens of liver cancer, knowing that the same year 48,700 new liver cancer cases were declared. Surgical procedures remain the options that offer the foremost success rate against such pathologies. Regretfully, surgery is not so frequent due to several limitations. Indeed, eligibility for liver surgery is based on the minimum safety liver volume remaining after resection (standardized FLR), but this minimum value varies over time and from one patient to another according to biological and mechanical properties of the liver. Since 1996, a large set of preoperative planning softwares has been developed, but all of them provide only the volume of the liver before and after resection. However interesting, this limited information is not sufficient to improve the rate of surgical eligibility. PASSPORT for Liver Surgery aims at overcoming these limitations by offering a patient-specific modelling that combines anatomical, mechanical, appearance and biological preoperative modelled information in a unified model of the patient. This first complete "Virtual liver" will be developed in an Open Source Framework allowing vertical integration of biomedical data, from macroscopic to microscopic patient information. From these models, a dynamic liver modelling will provide the patient-specific minimum safety standardized FLR in an educative and preoperative planning simulator allowing to predict the feasibility of the gesture and surgeons' ability to realise it. Thus, any patient will be able to know the risk level of a proposed therapy. Finally, we expect to increase the rate of surgical treatment so as to save patients with a liver pathology. To reach these purposes, PASSPORT is composed of a high level partnership between internationally renowned surgical teams, leading European research teams in surgical simulation and an international leading company in surgical instrumentation.
Fields of science
Call for proposal
FP7-ICT-2007-2
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Funding Scheme
CP - Collaborative project (generic)Coordinator
67091 Strasbourg Cedex
France
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Participants (16)
Participation ended
1348 Louvain La Neuve
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8092 Zuerich
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80333 Muenchen
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78532 TUTTLINGEN
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04109 Leipzig
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Participation ended
67070 Strasbourg
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67081 Strasbourg
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75654 Paris
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78153 Le Chesnay Cedex
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SW7 2AZ LONDON
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WC1E 6BT LONDON
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38031 Grenoble Cedex 1
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75654 PARIS
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75794 Paris
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38040 SAINT-MARTIN-D'HERES
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38041 GRENOBLE
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