Objective
Ischemic heart disease (IHD) is characterised by increased systemic oxidative stress status. Free radicals activate redox sensitive pathways responsible for the production of inflammatory mediators with key role in IHD. Statins have a beneficial role in coronary atherosclerosis, but their potential effect on key features in the pathophysiology of IHD is unclear. In this context, statins may have a beneficial effect in IHD by modifying myocardial and vascular redox signalling. In part A of the study, we will obtain segments of internal mammary arteries (IMA) and saphenous veins (SV) from 60 patients with ischemic heart disease (IHD) undergoing coronary bypass operation. In these vessels we will evaluate the direct effect of atorvastatin on the main sources of superoxide (O2-) radicals generation (uncoupled nitric oxide synthase (NOS) and NADPH-oxidase), by using an ex-vivo setup. We will also investigate the direct effect of atorvastatin on the expression of adipokines (cytokines with important paracrine/endocrine role in IHD) in different types of adipose tissue. We will also examine the individual effect of each adipokine on vascular redox state and signalling. In part B of the study, 60 patients with IHD will be randomised to receive atorvastatin 40mg/d (n=30) or placebo (n=30) for 7 days before their bypass operation. The effect of atorvastatin treatment on endothelial function will be examined by ultrasound in the brachial artery. The effect of atorvastatin on redox signalling (O2- and ONOO- radicals) and inflammatory pathways in myocardium, vascular wall, and human adipose tissue will also be evaluated. This will be the first study examining the effects of atorvastatin on redox state and the activation of redox-sensitive pathways in vascular wall and myocardium of patients with IHD. This study may provide the basis for the design of new clinical trials examining the effect of statins on clinical outcome of patients with IHD.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine physiology pathophysiology
- medical and health sciences clinical medicine cardiology cardiovascular diseases arteriosclerosis
- natural sciences physical sciences acoustics ultrasound
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2007-2-2-ERG
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
105 61 ATHINA
Greece
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.