Skip to main content

Genomics biomarkers of environmental health

Objective

This project concerns the first large-scale application of the full range of –omics technologies in a population study aiming at a) the discovery and validation of novel biomarkers predictive of increased risks of a number of chronic diseases, b) the exploration of the association of such biomarkers with environmental exposures, including high-priority pollutants and emerging exposures, and c) the discovery and validation of biomarkers of exposure to the above and other high-priority environmental exposures. The project will utilise three existing prospective cohorts. Cancer-related -omics biomarkers will be developed using a case-control study nested within 2 cohorts which contain biosamples collected prior to disease diagnosis, exposure and followup health information. Biomarkers will be compared in 600 breast cancer cases, 300 NHL cases and equal numbers of matched controls, to evaluate their risk predictivity. Biomarkers of chronic diseases which establish themselves in early childhood but persist into adult life will be evaluated using a mother-child cohort. Biosamples collected from 600 children at birth and at ages 2 and 4 years will be analysed and results compared with clinical indices obtained at age 4. Thanks to the availability of repeat samples, collected over a wide range of time intervals, the intra-individual variation of biomarkers and their relationship with disease progression will be evaluated. Biomarker search will utilize state-of-the-art metabonomics, epigenomics, proteomics and transcriptomics, in combination with advanced bioinformatics and systems biology tools. It will also include technical validation of -omics technology’s utilisation with biobank samples. Exposure assessment will utilize exposure biomarkers, questionnaires, modelling and GIS technology. Additional data on exposure, biomarkers (including SNP data) and health indices, available through other projects, will be utilised, thus generating substantial added value.

Field of science

  • /medical and health sciences/clinical medicine/cancer/breast cancer
  • /natural sciences/biological sciences/genetics and heredity/epigenetics

Call for proposal

FP7-ENV-2008-1
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

ETHNIKO IDRYMA EREVNON
Address
Vas Konstantinou 48
11635 Athina
Greece
Activity type
Research Organisations
EU contribution
€ 474 174,40
Administrative Contact
Soterios Kyrtopoulos (Prof.)

Participants (11)

UNIVERSITEIT MAASTRICHT
Netherlands
EU contribution
€ 643 091
Address
Minderbroedersberg 4-6
6200 MD Maastricht
Activity type
Higher or Secondary Education Establishments
Administrative Contact
René Reijnders (Mr.)
IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
United Kingdom
EU contribution
€ 437 001,20
Address
South Kensington Campus Exhibition Road
SW7 2AZ London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Michael Robinson (Mr.)
UMEA UNIVERSITET
Sweden
EU contribution
€ 324 900
Address
Universitetomradet
901 87 Umea
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Ellinor ädelroth (Dr.)
ISTITUTO PER LO STUDIO E LA PREVENZIONE E LA RETE ONCOLOGICA
Italy
EU contribution
€ 235 200
Address
Via Cosimo Il Vecchio 2
50139 Firenze
Activity type
Other
Administrative Contact
Elena Lacquaniti (Dr.)
PANEPISTIMIO KRITIS
Greece
EU contribution
€ 260 000,40
Address
University Campus Gallos
74100 Rethimno
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Eva Michelidaki (Ms.)
UNIVERSITEIT UTRECHT
Netherlands
EU contribution
€ 417 375
Address
Heidelberglaan 8
3584 CS Utrecht
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Monique Van Der Hoek (Ms.)
ISTITUTO SUPERIORE DI SANITA
Italy
EU contribution
€ 50 000,40
Address
Viale Regina Elena 299
00161 Roma
Activity type
Research Organisations
Administrative Contact
Rosa Maria Martoccia (Dr.)
TERVEYDEN JA HYVINVOINNIN LAITOS
Finland
EU contribution
€ 334 257,60
Address
Mannerheimintie 166
00271 Helsinki
Activity type
Research Organisations
Administrative Contact
Jaakko Penttinen (Mr.)
UNIVERSITY OF LEEDS
United Kingdom
EU contribution
€ 204 000
Address
Woodhouse Lane
LS2 9JT Leeds
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Kathy Brownridge (Ms.)
MAX IV Laboratory, Lund University
Sweden
EU contribution
€ 120 000
Address
Paradisgatan 5C
22100 Lund
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Bo Jönsson (Prof.)
NATIONAL TAIWAN UNIVERSITY
Taiwan
Address
Roosevelt Road 1
10617 Taipei
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Fang-Yu Hu (Ms.)