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Mathematical Modelling and Simulation of the Cardiovascular System

Objectif

This research project aims at the development, analysis and computer implementation of mathematical models of the cardiovascular system. Our goal is to describe and simulate the anatomic structure and the physiological response of the human cardiovascular system in healthy or diseased states. This demands to address many fundamental issues. Blood flow interacts both mechanically and chemically with the vessel walls and tissue, giving rise to complex fluid-structure interaction problems. The mathematical analysis of these problems is complicated and the related numerical analysis difficult. We propose to extend the recently achieved results on blood flow simulations by directing our analysis in several new directions. Our goal is to encompass aspects of metabolic regulation, micro-circulation, the electrical and mechanical activity of the heart, and their interactions. Modelling and optimisation of drugs delivery in clinical diseases will be addressed as well. This requires the understanding of transport, diffusion and reaction processes within the blood and organs of the body. The emphasis of this project will be put on mathematical modelling, numerical analysis, algorithm implementation, computational efficiency, validation and verification. Our purpose is to set up a mathematical simulation platform eventually leading to the improvement of vascular diseases diagnosis, setting up of surgical planning, and cure of inflammatory processes in the circulatory system. This platform might also help physicians to construct and evaluate combined anatomic/physiological models to predict the outcome of alternative treatment plans for individual patients.

Appel à propositions

ERC-2008-AdG
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Régime de financement

ERC-AG - ERC Advanced Grant

Institution d’accueil

ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
Adresse
Batiment Ce 3316 Station 1
1015 Lausanne
Suisse

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Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Caroline Vandevyver (Ms.)
Chercheur principal
Alfio Quarteroni (Prof.)
Contribution de l’UE
€ 1 293 720,40

Bénéficiaires (2)

ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
Suisse
Contribution de l’UE
€ 1 293 720,40
Adresse
Batiment Ce 3316 Station 1
1015 Lausanne

Voir sur la carte

Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Caroline Vandevyver (Ms.)
Chercheur principal
Alfio Quarteroni (Prof.)
POLITECNICO DI MILANO
Italie
Contribution de l’UE
€ 517 271,60
Adresse
Piazza Leonardo Da Vinci 32
20133 Milano

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Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Giuseppe Piampiano (Mr.)