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Contained Molecular Farming – Controllable Contained Systems for High Yield and Consistency

Objective

The CoMoFarm project will establish high-yielding production systems for pharmaceutical and industrial proteins based on plants, plant tissue and plant cells. The aim is to develop systems in which both the production host and the product itself show consistent yield and quality. The project will include a comparison of four alternative systems – hydroponic plants, root cultures, moss and suspension cells, and will involve the evaluation of different species, strain and process optimization, scale-up, downstream processing, protein characterization and process evaluation in terms of regulatory compliance. As well as furthering the development of an emerging production technology, the project will incorporate numerous innovative elements such as in-process monitoring and automation of environmental parameters to maintain a consistent environment and optimize protein yield and homogeneity, novel downstream processing technologies and innovative bioreactor and hydroponic designs to maintain plant health and ensure production according to good manufacturing practice. This project will have an immense impact on the biopharmaceuticals industry, by allowing SMEs interested in molecular farming to develop plant-made pharmaceuticals without worrying about regulatory constraints or poor investment prospects. This will go a long way to establishing molecular farming as a feasible industry within Europe, and will open new revenue streams for companies currently not interested in (or aware of) molecular farming, e.g. horticulture companies and nurseries. The cost of drugs will also begin to fall, which will positively re-enforce the benefits of plants and lead to greater growth in the market.

Field of science

  • /natural sciences/biological sciences/biochemistry/biomolecules/proteins
  • /agricultural sciences/animal and dairy science

Call for proposal

FP7-KBBE-2008-2B
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.
Address
Hansastrasse 27C
80686 Munchen
Germany
Activity type
Research Organisations
EU contribution
€ 828 617
Administrative Contact
Maximilian Steiert (Mr.)

Participants (9)

ZURCHER HOCHSCHULE FUR ANGEWANDTE WISSENSCHAFTEN
Switzerland
EU contribution
€ 58 659
Address
Gertrudstrasse 15
8401 Winterthur
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Dieter Eibl (Prof.)
TEKNOLOGIAN TUTKIMUSKESKUS VTT
Finland
EU contribution
€ 315 450
Address
Tekniikantie 4 A
02044 VTT Espoo
Activity type
Research Organisations
Administrative Contact
Irmeli Koskinen (Ms.)
RHEINISCH-WESTFAELISCHE TECHNISCHE HOCHSCHULE AACHEN
Germany
EU contribution
€ 232 320
Address
Templergraben 55
52062 Aachen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Ernst Schmachtenberg (Prof.)
ST GEORGE'S HOSPITAL MEDICAL SCHOOL
United Kingdom
EU contribution
€ 438 399
Address
Cranmer Terrace
SW17 0RE London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Paul Craven (Dr.)
FORSCHUNGSZENTRUM JULICH GMBH
Germany
EU contribution
€ 251 972
Address
Wilhelm Johnen Strasse
52428 Julich
Activity type
Research Organisations
Administrative Contact
Petra Insberg (Ms.)
GREENOVATION BIOTECH GMBH
Germany
EU contribution
€ 326 370
Address
Botzinger Strasse 29B
79111 Freiburg
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Danielle Pueschel (Ms.)
Dow AgroSciences LLC
United States
Address
Zionsville Road 9330
46268-1054 Indianapolis
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Ronald Maciak (Mr.)
ADOLF KUHNER AG
Switzerland
EU contribution
€ 154 710
Address
Dinkelbergstrasse 1
4127 Birsfelden
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Tibor Anderlei (Dr.)
STICHTING WAGENINGEN RESEARCH
Netherlands
EU contribution
€ 228 300
Address
Droevendaalsesteeg 4
6708 PB Wageningen
Activity type
Research Organisations
Administrative Contact
Leny Versteeg-Brouwer (Ms.)