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RISK ASSESSMENT OF ENGINEERED NANOPARTICLES

Obiettivo

Engineered Nanoparticles (ENP) are increasingly produced for use in a wide range of industrial and consumer products. Yet it is known that exposure to some types of particles can cause severe health effects. Therefore it is essential to ascertain whether exposure to ENP can lead to possible health risks for workers and consumers. We have formed a consortium of well-known scientists from European Universities and Research Institutes, with over 100 publications in the field of Nanotoxicology. Our aim is to develop an approach for the Risk Assessment of ENP (ENPRA). Our objectives are: (i) to obtain a bank of commercial ENP with contrasting physico-chemical characteristics and measure them; (ii) to investigate the toxic effects of ENP on 5 (pulmonary, hepatic, renal, cardiovascular and developmental) target systems and 5 endpoints (oxidative stress, inflammation; immuno-toxicity; fibrogenecity; genotoxicity) using in vitro animal/human models; (iii) to validate the in vitro findings with a small set of carefully chosen in vivo animal experiments; (iv) to construct mathematical models to extrapolate the exposure-dose-response relationship from in vitro to in vivo and to humans; (v) to use QSAR like models to identify the key ENP characteristics driving the adverse effects; (vi) to implement a risk assessment of ENP using the Weight-of-Evidence approach; (vii) to disseminate our findings to potential stakeholders. To harmonise the research activities between our EU group and the US, we have established links with scientists from US Universities (Duke, Rochester) and Government Agencies (NIH/NIEHS, NIOSH and EPA) with on-going research in Nanotoxicology. Our objectives here are (vii) to share information and agree on experimental protocols; (viii) to avoid duplication of work; (ix) to further validate the findings of this proposed study.

Campo scientifico

Parole chiave

Programma(i)

Argomento(i)

Invito a presentare proposte

FP7-NMP-2008-SMALL-2
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Meccanismo di finanziamento

CP-FP - Small or medium-scale focused research project

Coordinatore

INSTITUTE OF OCCUPATIONAL MEDICINE
Contributo UE
€ 400 680,00
Indirizzo
Research Avenue North, Riccarton 45
EH14 4AP Edinburgh
Regno Unito

Mostra sulla mappa
Regione
Scotland Eastern Scotland Edinburgh
Tipo di attività
Research Organisations
Contatto amministrativo
Susy Scarisbrick (Ms.)
Collegamenti
Costo totale
Nessun dato

Partecipanti (17)

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Ultimo aggiornamento: 25 Maggio 2022

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Permalink: https://cordis.europa.eu/project/id/228789/it

European Union, 2024