Folate-based nanobiodevices for integrated diagnosis/therapy targeting chronic inflammatory diseases

Informations projet

NANOFOL

N° de convention de subvention: 228827

Projet clôturé

Date de début 1 Decembre 2009

Date de fin 30 Novembre 2013

Financé au titre de

• Specific Programme "Cooperation": Nanosciences, Nanotechnologies, Materials and new Production Technologies

Coût total € 6 635 409,43

Contribution de l’UE € 5 149 874,00

Coordonné par

UNIVERSIDADE DO MINHO
Portugal

Objectif

NANOFOL proposes to develop a new diagnostic/therapy approach using folate based nanobiodevices (FBN) able to provide a new type of cost efficient treatment for chronic inflammatory diseases such as Atherosclerosis and Rheumatoid Arthritis with low side effects that will constitute a more advantageous solution than current therapies. NANOFOL will achieve all that by fulfilling the following objectives: •Design , development and production of nanobiodevices (FBN) targeting directly effector cells •Proof of concept in vitro and in vivo of a folate based nanodevice targeting activated macrophages in chronic inflammation not affecting bystander cells •Proof of concept in vitro and in vivo of a nanodevice containing a bispecific antibody (against folate receptor and another macrophage marker) targeting activated macrophages in chronic inflammation not affecting bystander cells •Proof of concept of FBN delivery therapeutic agents (by small interfering ribonucleic acid molecules (siRNA) or lipophylic molecules) targeting inflammatory signaling pathways •In vitro and in vivo testing of cellular toxicity caused by the novel nanobiodevices in cells other than activated macrophages •Design of models that will enable to minimize animal experimentation. •Development of a strategy to assess potential risks in order to ensure nanobiodevice safe delivery. NANOFOL has adopted a specific risk strategy to attain objectives in a step by step approach allowing improving gradually the concept (specificity, stability, side effects efficacy) from the lower to the higher risky solutions ensuring reduced experimental animal testing and high human safety. The NANOFOL project will combine expertise in nanotechnologies, biology, chemistry, materials science, biotechnology, engineering, risk analysis, medical and pharmaceutical sciences.

Champ scientifique

• medical and health sciences › clinical medicine › rheumatology
• medical and health sciences › health sciences › inflammatory diseases
• medical and health sciences › clinical medicine › cardiology › cardiovascular diseases › arteriosclerosis
• engineering and technology › nanotechnology

Programme(s)

• FP7-NMP - Specific Programme "Cooperation": Nanosciences, Nanotechnologies, Materials and new Production Technologies

Thème(s)

• NMP-2008-4.0-1 - Development of nanotechnology-based systems for diagnosis and/or therapy for diabetes, muscolo-skeletal or inflammatory diseases (in coordination with Theme HEALTH)

Appel à propositions

FP7-NMP-2008-LARGE-2
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Régime de financement

CP-IP - Large-scale integrating project

Coordinateur

UNIVERSIDADE DO MINHO

• Contribution de l’UE: € 1 054 530,00
• Adresse: LARGO DO PACO ; 4704 553 Braga ; Portugal
• Région: Continente › Norte › Cávado
• Type d’activité: Higher or Secondary Education Establishments
• Contact administratif: Vasco Manuel Pinto Texeira (Prof.)
• Coût total: Aucune donnée

Participants (13)

SUAN FARMA S.A.

Espagne

• Contribution de l’UE: € 125 572,55
• Adresse: Einstein 8 ; 28108 Alcobendas
• Type d’activité: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Contact administratif: Ion Arocena Velez (Mr.)
• Coût total: Aucune donnée

TECHNISCHE UNIVERSITAET GRAZ

Participation terminée

Autriche

• Contribution de l’UE: € 304 036,84
• Adresse: RECHBAUERSTRASSE 12 ; 8010 Graz
• Région: Südösterreich › Steiermark › Graz
• Type d’activité: Higher or Secondary Education Establishments
• Contact administratif: Georg Guebitz (Prof.)
• Coût total: Aucune donnée

NEDERLANDSE ORGANISATIE VOOR TOEGEPAST NATUURWETENSCHAPPELIJK ONDERZOEK TNO

Pays-Bas

• Contribution de l’UE: € 453 858,53
• Adresse: ANNA VAN BUERENPLEIN 1 ; 2595 DA Den Haag
• Région: West-Nederland › Zuid-Holland › Agglomeratie ’s-Gravenhage
• Type d’activité: Research Organisations
• Contact administratif: Herman Lenting (Dr.)
• Coût total: Aucune donnée

INSTITUTO DE BIOLOGIA MOLECULAR E CELULAR-IBMC

Portugal

• Contribution de l’UE: € 314 437,56
• Adresse: RUA ALFREDO ALLEN 208 ; 4200 135 Porto
• Région: Continente › Norte › Área Metropolitana do Porto
• Type d’activité: Research Organisations
• Contact administratif: Claudia Ferreira (Dr.)
• Coût total: Aucune donnée

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

France

• Contribution de l’UE: € 522 780,00
• Adresse: RUE DE TOLBIAC 101 ; 75654 Paris
• Région: Ile-de-France › Ile-de-France › Paris
• Type d’activité: Research Organisations
• Contact administratif: Tiphaine Guida (Mrs.)
• Coût total: Aucune donnée

MEDIZINISCHE UNIVERSITAET WIEN

Autriche

• Contribution de l’UE: € 452 432,55
• Adresse: SPITALGASSE 23 ; 1090 Wien
• Région: Ostösterreich › Wien › Wien
• Type d’activité: Higher or Secondary Education Establishments
• Contact administratif: Hannes Stockinger (Prof.)
• Coût total: Aucune donnée

UNIVERSITATEA AUREL VLAICU DIN ARAD

Roumanie

• Contribution de l’UE: € 285 175,25
• Adresse: BULEVARD REVOLUTIEI 77 ; 310130 Arad
• Type d’activité: Higher or Secondary Education Establishments
• Contact administratif: Ramona Lile (Prof.)
• Coût total: Aucune donnée

SYNOVO GMBH

Allemagne

• Contribution de l’UE: € 368 373,90
• Adresse: Paul Ehrlich Str 15 ; 72076 Tuebingen
• Région: Baden-Württemberg › Tübingen › Tübingen, Landkreis
• Type d’activité: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Contact administratif: Michael Burnet (Dr.)
• Coût total: Aucune donnée

INSTITUT NATIONAL DE L ENVIRONNEMENT INDUSTRIEL ET DES RISQUES - INERIS

France

• Contribution de l’UE: € 468 319,00
• Adresse: PARC TECHNOLOGIQUE ALATA ; 60550 Verneuil En Halatte
• Région: Hauts-de-France › Picardie › Oise
• Type d’activité: Research Organisations
• Contact administratif: Lydia Boutigny (Ms.)
• Coût total: Aucune donnée

EXBIO PRAHA AS

Tchéquie

• Contribution de l’UE: € 418 175,60
• Adresse: Nad Safinou II, 366 ; 25242 VESTEC
• Type d’activité: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Contact administratif: Stanislav Lancouch
• Coût total: Aucune donnée

AYMING

France

• Contribution de l’UE: € 213 007,00
• Adresse: RUE CHAPTAL 114 ; 92300 Levallois-Perret
• Région: Ile-de-France › Ile-de-France › Hauts-de-Seine
• Type d’activité: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Contact administratif: Maud Bossard (Ms.)
• Coût total: Aucune donnée

Alfama - Investigacao e Desenvolvimento de Produtos Farmaceuticos, Lda.

Participation terminée

Portugal

• Contribution de l’UE: € 21 767,53
• Adresse: Av. da Republica, Quinta do Marques, Estacao Agronomica Nacional IBET/ITQB, Lab.7.14 ; 2780-157 Oeiras
• Type d’activité: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Coût total: Aucune donnée

UNIVERSITAET FUER BODENKULTUR WIEN

Autriche

• Contribution de l’UE: € 147 407,69
• Adresse: GREGOR MENDEL STRASSE 33 ; 1180 Wien
• Région: Ostösterreich › Wien › Wien
• Type d’activité: Higher or Secondary Education Establishments
• Contact administratif: Georg Guebitz (Prof.)
• Coût total: Aucune donnée