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Folate-based nanobiodevices for integrated diagnosis/therapy targeting chronic inflammatory diseases

Objectif

NANOFOL proposes to develop a new diagnostic/therapy approach using folate based nanobiodevices (FBN) able to provide a new type of cost efficient treatment for chronic inflammatory diseases such as Atherosclerosis and Rheumatoid Arthritis with low side effects that will constitute a more advantageous solution than current therapies. NANOFOL will achieve all that by fulfilling the following objectives: •Design , development and production of nanobiodevices (FBN) targeting directly effector cells •Proof of concept in vitro and in vivo of a folate based nanodevice targeting activated macrophages in chronic inflammation not affecting bystander cells •Proof of concept in vitro and in vivo of a nanodevice containing a bispecific antibody (against folate receptor and another macrophage marker) targeting activated macrophages in chronic inflammation not affecting bystander cells •Proof of concept of FBN delivery therapeutic agents (by small interfering ribonucleic acid molecules (siRNA) or lipophylic molecules) targeting inflammatory signaling pathways •In vitro and in vivo testing of cellular toxicity caused by the novel nanobiodevices in cells other than activated macrophages •Design of models that will enable to minimize animal experimentation. •Development of a strategy to assess potential risks in order to ensure nanobiodevice safe delivery. NANOFOL has adopted a specific risk strategy to attain objectives in a step by step approach allowing improving gradually the concept (specificity, stability, side effects efficacy) from the lower to the higher risky solutions ensuring reduced experimental animal testing and high human safety. The NANOFOL project will combine expertise in nanotechnologies, biology, chemistry, materials science, biotechnology, engineering, risk analysis, medical and pharmaceutical sciences.

Appel à propositions

FP7-NMP-2008-LARGE-2
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Coordinateur

UNIVERSIDADE DO MINHO
Adresse
Largo Do Paco
4704 553 Braga
Portugal

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Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Vasco Manuel Pinto Texeira (Prof.)
Contribution de l’UE
€ 1 054 530

Participants (13)

SUAN FARMA S.A.
Espagne
Contribution de l’UE
€ 125 572,55
Adresse
Einstein 8
28108 Alcobendas

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Type d’activité
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contact administratif
Ion Arocena Velez (Mr.)
TECHNISCHE UNIVERSITAET GRAZ

Participation terminée

Autriche
Contribution de l’UE
€ 304 036,84
Adresse
Rechbauerstrasse 12
8010 Graz

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Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Georg Guebitz (Prof.)
NEDERLANDSE ORGANISATIE VOOR TOEGEPAST NATUURWETENSCHAPPELIJK ONDERZOEK TNO
Pays-Bas
Contribution de l’UE
€ 453 858,53
Adresse
Anna Van Buerenplein 1
2595 DA Den Haag

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Type d’activité
Research Organisations
Contact administratif
Herman Lenting (Dr.)
INSTITUTO DE BIOLOGIA MOLECULAR E CELULAR-IBMC
Portugal
Contribution de l’UE
€ 314 437,56
Adresse
Rua Alfredo Allen 208
4200 135 Porto

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Type d’activité
Research Organisations
Contact administratif
Claudia Ferreira (Dr.)
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
Contribution de l’UE
€ 522 780
Adresse
Rue De Tolbiac 101
75654 Paris

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Type d’activité
Research Organisations
Contact administratif
Tiphaine Guida (Mrs.)
MEDIZINISCHE UNIVERSITAET WIEN
Autriche
Contribution de l’UE
€ 452 432,55
Adresse
Spitalgasse 23
1090 Wien

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Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Hannes Stockinger (Prof.)
UNIVERSITATEA AUREL VLAICU DIN ARAD
Roumanie
Contribution de l’UE
€ 285 175,25
Adresse
Bulevard Revolutiei 77
310130 Arad

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Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Ramona Lile (Prof.)
SYNOVO GMBH
Allemagne
Contribution de l’UE
€ 368 373,90
Adresse
Paul Ehrlich Str 15
72076 Tuebingen

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Type d’activité
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contact administratif
Michael Burnet (Dr.)
INSTITUT NATIONAL DE L ENVIRONNEMENT INDUSTRIEL ET DES RISQUES - INERIS
France
Contribution de l’UE
€ 468 319
Adresse
Parc Technologique Alata
60550 Verneuil En Halatte

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Type d’activité
Research Organisations
Contact administratif
Lydia Boutigny (Ms.)
EXBIO PRAHA AS
Tchéquie
Contribution de l’UE
€ 418 175,60
Adresse
Nad Safinou Ii, 366
25242 Vestec

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Type d’activité
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contact administratif
Stanislav Lancouch
AYMING
France
Contribution de l’UE
€ 213 007
Adresse
Rue Chaptal 114
92300 Levallois-perret

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Type d’activité
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contact administratif
Maud Bossard (Ms.)
Alfama - Investigacao e Desenvolvimento de Produtos Farmaceuticos, Lda.

Participation terminée

Portugal
Contribution de l’UE
€ 21 767,53
Adresse
Av. Da Republica, Quinta Do Marques, Estacao Agronomica Nacional Ibet/itqb, Lab.7.14
2780-157 Oeiras

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Type d’activité
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contact administratif
UNIVERSITAET FUER BODENKULTUR WIEN
Autriche
Contribution de l’UE
€ 147 407,69
Adresse
Gregor Mendel Strasse 33
1180 Wien

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Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Georg Guebitz (Prof.)