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Integrated Micro-Nano-Opto Fluidic systems for high-content diagnosis and studies of rare cancer cells

Objective

The project aims at developing a new integrated and automated microfluidic tool for cancer cells screening. This instrument will have a reliability and power much beyond state of the art (capture yield increased by a factor from 10X to 100X and multimodal typing of the cells in 3D high resolution images), allowing earlier and more accurate diagnosis, prognosis and selection of treatments of cancers. CaMiNEMS’s new approach will involve a new generation of bio-functionalised multifunctional magnetic nano and microparticles which will be self-assembled by a Hierarchial Templated Self-Assembly mechanism into high-aspect ratio reversible arrays. For highly automated molecular typing of cancers, this key innovation will be integrated with a unique fully automated flow control system working from nanolitres to millilitres and with innovative nano-optics tools and image analysis software. Technological developments will be validated regarding the analysis of circulating tumour cells or “micrometastases” and the molecular typing of minimally invasive microsamples from tumours. The project will also yield new tools for research and drug-discovery, allowing for the first time to study at the single molecule scale in single cancer cells from patients the fate and action of new generation anticancer drugs using innovative dynamic tracking of Quantum dots. To combine research excellence and societal impact, the consortium involves research groups with complementary competences in microfluidics, nano-optics, biophysics, nanoparticles, biochemistry, informatics, several forefront cancer centres for clinical validation and a research-intensive SME for exploitation.

Field of science

  • /natural sciences/computer and information sciences/software
  • /natural sciences/biological sciences/biophysics
  • /natural sciences/biological sciences/biochemistry
  • /medical and health sciences/clinical medicine/oncology/cancer

Call for proposal

FP7-NMP-2008-SMALL-2
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

INSTITUT CURIE
Address
Rue D'ulm 26
75231 Paris
France
Activity type
Research Organisations
EU contribution
€ 847 533
Administrative Contact
Corinne Cumin (Ms.)

Participants (8)

UNIVERZITA PARDUBICE
Czechia
EU contribution
€ 407 041
Address
Studentska 95
532 10 Pardubice
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Lucie Machacova (Ms.)
USTAV MAKROMOLEKULARNI CHEMIE AV CRVVI
Czechia
EU contribution
€ 395 540
Address
Heyrovsky Sq 2
162 06 Praha 6
Activity type
Research Organisations
Administrative Contact
Jan Kouba (Mr.)
FLUIGENT SA
France
EU contribution
€ 536 480
Address
57-77 Avenue De Fontainebleau
94270 Le Kremlin-bicetre
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Nicolas Guyot (Mr.)
IPATIMUP - INSTITUTO DE PATOLOGIA E IMUNOLOGIA MOLECULAR DA UNIVERSIDADE DO PORTO PCUP
Portugal
EU contribution
€ 193 082
Address
Rua Julio Amaral De Carvalho 45
4200 135 Porto
Activity type
Research Organisations
Administrative Contact
Ana Sofia Santos Silva (Dr.)
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom
EU contribution
€ 453 983
Address
Wellington Square University Offices
OX1 2JD Oxford
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Chris Scotcher (Mr.)
INSTITUT GUSTAVE ROUSSY
France
EU contribution
€ 268 180
Address
Rue Camille Desmoulins 39
94805 Villejuif
Activity type
Research Organisations
Administrative Contact
Arnauld Forest (Mr.)
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
Germany
EU contribution
€ 354 264
Address
Geschwister Scholl Platz 1
80539 Muenchen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Christian Schindlbeck (Dr.)
AYMING
France
EU contribution
€ 95 040
Address
185 Avenue Des Gresillons
92622 Gennevilliers Cedex
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Nicolas Marin (Mr.)