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Nanoscopically-guided induction and expansion of regulatory hematopoietic cells to treat autoimmune and inflammatory processes

Objective

We propose a multidisciplinary program, focusing on the development of novel approaches for directing the differentiation, proliferation and tissue-tropism of specific hematopoietic lineages, using micro- and nano-fabricated cell chips. We will use advanced nanofabricated surfaces functionalized with specific biomolecules, and microfluidics cell chips to specify and expend regulatory immune cells for treating diverse inflammatory and autoimmune disorders in an organ- and antigen-specific manner. The proposed cell-chip will create ex-vivo microenvironments mimicking in-vivo cell-cell interactions and molecular signals involved in differentiation and proliferation of hematopoietic cells. Cell chip development and optimization will be supported by high throughput microscopy to select for optimal conditions. “Educated” cells will be employed for in vivo experiments in mice and the methodology will be further adapted for human cell populations, and applied for clinical diagnosis and therapy as well as the developments of clinically-relevant devices. Regulatory T-cells are extremely promising cells for treatment of inflammatory and auto-immune disease, as well as for tolerance induction in organ transplantation. To be effective they must be produced conveniently, at large numbers with an optimally tuned phenotype. The methodology is suggested to overcome current obstacles in obtaining therapeutically significant numbers of T cells. We propose to apply the suggested methodology for treating different inflammatory or autoimmune diseases including type-1 diabetes using targeted immunotherapeutic approaches. Developing new methods for producing large numbers of finely-tuned and tissue-targeted regulatory cells will make this approach clinically viable. This novel methodology can be extended to directing differentiation of other specific T-cell and hematopoietic lineages, with possible applications for targeting other autoimmune diseases and treating tumors or graft rejection.

Field of science

  • /medical and health sciences/basic medicine/immunology/autoimmune diseases
  • /natural sciences/physical sciences/classical mechanics/fluid mechanics/microfluidics

Call for proposal

FP7-NMP-2008-LARGE-2
See other projects for this call

Funding Scheme

CP-IP - Large-scale integrating project

Coordinator

Klinik Max Planck Institut für Psychiatrie
Address
Hofgartenstrasse 8
80539 Muenchen
Germany
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
EU contribution
€ 953 200
Administrative Contact
Joachim Spatz (Prof.)

Participants (15)

WEIZMANN INSTITUTE OF SCIENCE
Israel
EU contribution
€ 1 101 650
Address
Herzl Street 234
7610001 Rehovot
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Talia Tzahor (Ms.)
EBERHARD KARLS UNIVERSITAET TUEBINGEN
Germany
EU contribution
€ 195 000
Address
Geschwister-scholl-platz
72074 Tuebingen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Rupert Handgretinger (Prof.)
UNIVERSITAETSKLINIKUM WUERZBURG - KLINIKUM DER BAYERISCHEN JULIUS-MAXIMILIANS-UNIVERSITAT
Germany
EU contribution
€ 202 500
Address
Josef-schneider-strasse 2
97080 Wurzburg
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Werner Buser (Mr.)
UNIVERSITA DEGLI STUDI DI PERUGIA
Italy
EU contribution
€ 225 000
Address
Piazza Dell Universita 1
06123 Perugia
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Roberto Quartesan (Prof.)
MEDICAL RESEARCH INFRASTRUCTURE DEVELOPMENT AND HEALTH SERVICES FUND BY THE SHEBA MEDICAL CENTER
Israel
EU contribution
€ 200 000
Address
Tel Hashomer Sheba Medical Center
52621 Ramat Gan
Activity type
Research Organisations
Administrative Contact
Gideon Rechavi (Prof.)
UNIVERSITETET I BERGEN
Norway
EU contribution
€ 279 000
Address
Museplassen 1
5020 Bergen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Inger Gjesdahl (Ms.)
CHALMERS TEKNISKA HOEGSKOLA AB
Sweden
EU contribution
€ 187 500
Address
-
41296 Goeteborg
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Annika Hofling (Ms.)
SCUOLA NORMALE SUPERIORE
Italy
EU contribution
€ 288 000
Address
Piazza Dei Cavalieri 7
56126 Pisa
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Daniele Altamore (Dr.)
ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
Switzerland
EU contribution
€ 492 500
Address
Batiment Ce 3316 Station 1
1015 Lausanne
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Harm - Anton Klok (Prof.)
MILTENYI BIOTEC GMBH
Germany
EU contribution
€ 250 000
Address
Friedrich Ebert Strasse 68
51429 Bergish Gladbach
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Michael Apel (Dr.)
CELLMADE SAS
France
EU contribution
€ 128 880
Address
Rue De La Cure 16
63720 Chappes
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Ronald Bronsaer (Mr.)
Idea Bio-Medical Ltd.
Israel
EU contribution
€ 351 250
Address
Prof. Bergman St. 2
76705 Rehovot
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Yuval Keren (Mr.)
Genome Identification Diagnostics GmbH
Germany
EU contribution
€ 277 200
Address
Ebinger Str. 4
72479 Strassberg
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Volkmar Schoellhorn (Dr.)
CellTech Services Götz GmbH

Participation ended

Germany
Address
Uhlandstr. 16
63500 Seligenstadt
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Alexander Götz (Dr.)
EVERCYTE GMBH
Austria
EU contribution
€ 178 320
Address
Leberstrasse 20/8
1110 Wien
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Otto Kanzler (Mr.)