Cel
We propose a multidisciplinary program, focusing on the development of novel approaches for directing the differentiation, proliferation and tissue-tropism of specific hematopoietic lineages, using micro- and nano-fabricated cell chips. We will use advanced nanofabricated surfaces functionalized with specific biomolecules, and microfluidics cell chips to specify and expend regulatory immune cells for treating diverse inflammatory and autoimmune disorders in an organ- and antigen-specific manner. The proposed cell-chip will create ex-vivo microenvironments mimicking in-vivo cell-cell interactions and molecular signals involved in differentiation and proliferation of hematopoietic cells. Cell chip development and optimization will be supported by high throughput microscopy to select for optimal conditions. “Educated” cells will be employed for in vivo experiments in mice and the methodology will be further adapted for human cell populations, and applied for clinical diagnosis and therapy as well as the developments of clinically-relevant devices. Regulatory T-cells are extremely promising cells for treatment of inflammatory and auto-immune disease, as well as for tolerance induction in organ transplantation. To be effective they must be produced conveniently, at large numbers with an optimally tuned phenotype. The methodology is suggested to overcome current obstacles in obtaining therapeutically significant numbers of T cells. We propose to apply the suggested methodology for treating different inflammatory or autoimmune diseases including type-1 diabetes using targeted immunotherapeutic approaches. Developing new methods for producing large numbers of finely-tuned and tissue-targeted regulatory cells will make this approach clinically viable. This novel methodology can be extended to directing differentiation of other specific T-cell and hematopoietic lineages, with possible applications for targeting other autoimmune diseases and treating tumors or graft rejection.
Dziedzina nauki
- natural sciencesphysical sciencesclassical mechanicsfluid mechanicsmicrofluidics
- natural sciencesbiological sciencesbiochemistrybiomolecules
- medical and health sciencesclinical medicineendocrinologydiabetes
- medical and health sciencesbasic medicineimmunologyautoimmune diseases
- medical and health sciencesclinical medicinetransplantation
Zaproszenie do składania wniosków
FP7-NMP-2008-LARGE-2
Zobacz inne projekty w ramach tego zaproszenia
System finansowania
CP-IP - Large-scale integrating projectKoordynator
80539 Munchen
Niemcy
Zobacz na mapie
Uczestnicy (15)
7610001 Rehovot
Zobacz na mapie
72074 Tuebingen
Zobacz na mapie
97080 Wurzburg
Zobacz na mapie
06123 Perugia
Zobacz na mapie
52621 Ramat Gan
Zobacz na mapie
5020 Bergen
Zobacz na mapie
412 96 GOTEBORG
Zobacz na mapie
56126 Pisa
Zobacz na mapie
1015 Lausanne
Zobacz na mapie
51429 Bergish Gladbach
Zobacz na mapie
63720 CHAPPES
Zobacz na mapie
76705 Rehovot
Zobacz na mapie
72479 Strassberg
Zobacz na mapie
Zakończenie uczestnictwa
63500 Seligenstadt
Zobacz na mapie
1110 Wien
Zobacz na mapie