Skip to main content
Weiter zur Homepage der Europäischen Kommission (öffnet in neuem Fenster)
Deutsch de
CORDIS - Forschungsergebnisse der EU
CORDIS
Inhalt archiviert am 2024-05-29

Peptide-mediated signalling in plant disease resistance

Ziel

Plants use complex recognition and response mechanisms to protect themselves from pathogen attack.

Major resistance (R) genes specify recognition of pathogens carrying the corresponding avirulence genes leading to the rapid activation of a battery of inducible defences that is often accompanied by the collapse of challenged plant cells in the hypersensitive response (HR), which results in a restricted lesion clearly delimited from surrounding healthy tissue.

In addition, immunity to subsequent attack by a b road range of normally virulent pathogens, so-called systemic acquired resistance (SAR), develops throughout the plant. CDR1 that encode an apoplastic aspartic protease, mediates a peptide signal system involved in the activation of inducible resistance mechanisms.

CDR1 overexpression causes dwarfing and resistance to virulent Pseudomonas syringae. Antisense CDR1 plants were compromised for resistance to avirulent P. syringae and more susceptible to virulent strains than wild type. Little is known about peptide signalling in plants although this mechanism is a regulatory paradigm in animals.

Genetics and biochemical dissection of the CDR1-mediated peptide signal in the model plant Arabidopsis should have an impact well beyond the disease resistance area. The aim of this proposal is determine the nature of the peptide signal generated by CDR1 action. Proteomic techniques or expression of epitope-tagged active site mutants will be used to direct identification of candidate peptides.

In addition, phenotypic analysis of CDR1 over-expression and antisense lines crossed with other key signal mutants will help to establish how CDR1 is integrated within the disease resistance signal network and the physiological properties of the peptide signal system.

The project will strengthen the experience of the candidate in Plant Molecular Biology, Genetic and Functional Proteomic and will enhance significantly the transfer of knowledge and expertise within the EC.

Wissenschaftliches Gebiet (EuroSciVoc)

Schlüsselbegriffe

Thema/Themen

Aufforderung zur Vorschlagseinreichung

FP6-2004-MOBILITY-5
Andere Projekte für diesen Aufruf anzeigen

Finanzierungsplan

EIF - Marie Curie actions-Intra-European Fellowships

Koordinator

JOHN INNES CENTRE
EU-Beitrag
Keine Daten
Adresse
Norwich Research Park, Colney
NORWICH
Vereinigtes Königreich
Links
Gesamtkosten
Keine Daten