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ER Stress and Photoreceptor Degeneration in Drosophila

Ziel

The endoplasmic reticulum (ER) is the cell organelle where secretory and membrane proteins are synthesized and folded. The presence of unfolded/misfolded proteins in the ER causes stress to the cell (“ER stress”) and activates the Unfolded Protein Response (UPR), a cellular response to restore homeostasis in the ER. The presence of misfolded proteins and activation of the UPR have been connected with many diseases and pathological conditions. My goal is to elucidate the molecular mechanisms that regulate neuronal degeneration and cell death induced by ER strees, using Drosophila melanogaster as a model system. To achieve this goal, I propose the following specific aims: 1. Analysis of the molecular mechanisms required for induction of cell death in the context of ER stress. 2. The mechanism of induction of cell death by Xbp1spliced 3. Developmental role of the UPR during photoreceptor differentiation.

Aufforderung zur Vorschlagseinreichung

FP7-PEOPLE-IRG-2008
Andere Projekte für diesen Aufruf anzeigen

Koordinator

INSTITUTO DE TECNOLOGIA QUIMICA E BIOLOGICA - UNIVERSIDADE NOVA DE LISBOA
Adresse
Avenida Da Republica, Estacao Agronomica Nacional
2784-505 Oeiras
Portugal
Aktivitätstyp
Higher or Secondary Education Establishments
EU-Beitrag
€ 100 000
Kontakt Verwaltung
Pedro Domingos (Mr.)